Recent Advances in Lipid Peroxidation: Mechanisms and Inhibitors
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 August 2026
Special Issue Editor
Special Issue Information
Dear Colleagues,
Autoxidation, a spontaneous, free-radical chain reaction mediated by peroxyl radicals, represents a critical pathway of oxidative damage in biological systems. As fundamental components of cellular membranes, lipids are particularly susceptible to autoxidation due to their diverse structures and degrees of unsaturation, which not only accelerate the reaction kinetics but also lead to a complex distribution of oxidation products. The implications of lipid peroxidation are profound, with critical roles in the pathogenesis of numerous human diseases, including cardiovascular disease, cancer, and neurodegenerative disorders. A landmark recent discovery has identified the peroxidation of membrane-bound polyunsaturated fatty acids (PUFAs) as the chemical basis of ferroptosis—a unique, iron-dependent form of regulated cell death distinct from apoptosis, necrosis, and autophagy. This finding has revitalized interest in the field, underscoring the urgent need to elucidate the underlying chemical mechanisms, biological consequences, and therapeutic inhibitory strategies.
This Special Issue aims to present original research and review articles that advance our understanding of lipid peroxidation and its inhibition. We welcome contributions spanning the chemistry and biology of lipid oxidation, including studies on its molecular mechanisms, its role in disease and cell death pathways (such as ferroptosis), and the development of novel antioxidant defenses and inhibitory strategies.
We invite you to share your latest discoveries and insights to foster a comprehensive discussion in this pivotal area of research.
Dr. Zijun Wu
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lipid autoxidation
- peroxyl radical
- redox biology
- oxidative stress
- antioxidant
- ferroptosis
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