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Special Issue "Stable radicals: synthesis, structure and applications"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 30 September 2020.

Special Issue Editor

Prof. Elena G. Bagryanskaya
E-Mail Website
Guest Editor
Novosibirsk State University, Novosibirsk, Russian Federation
Interests: pulse dipole EPR; nitroxide radicals; triarylmethyl radicals; NMR; DNP; electron spin relaxation; nitroxide-mediated radical polymerization; spin probes and spin labels; supramolecular complexes; biopolymers

Special Issue Information

Dear Colleagues,

Stable radicals are molecules with one or several unpaired electron spins on their outer shell. Nitroxide and triarylmethyl radicals are the most important classes of stable radicals. The discovery and development of electron paramagnetic spectroscopy has stimulated great interest in the chemistry of stable radicals. During recent decades, the application of stable radicals has expanded significantly, encompassing many scientific fields. For example, stable radicals have been used as building blocks in molecular magnetics, as mediators in controlled radical polymerization, as spin labels in structural biology, as spin probes in EPR tomography, as contrast agents in MRI, and as polarizing agents in dynamic nuclear polarization, to name but a few.

Great progress has been made in the synthesis of different stable radicals with very fancy functional properties, such as high stability, narrow EPR lines, etc. The main aim of the Special Issue on “Stable Radicals: Synthesis, Structure, and Applications” is to provide an open forum where researchers may share their investigations and findings in this promising field and, thanks to the open access platform, increase their visibility. Contributions to this issue, in the form of both original research and review articles, may cover all aspects of the synthesis of stable radicals, the study of their chemical and physical properties, and different applications; studies with multidisciplinary input that offer new methodologies or insights are particularly welcome.

Prof. Dr. Elena Bagryanskaya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nitroxide radicals
  • triarylmethyl radicals
  • spin labels
  • spin probes
  • pulse dipole EPR spectroscopy
  • EPR tomography
  • synthesis of stable radicals
  • nitroxide-mediated polymerization

Published Papers (1 paper)

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Research

Open AccessArticle
2-Butyl-2-tert-butyl-5,5-diethylpyrrolidine-1-oxyls: Synthesis and Properties
Molecules 2020, 25(4), 845; https://doi.org/10.3390/molecules25040845 (registering DOI) - 14 Feb 2020
Abstract
Nitroxides are broadly used as molecular probes and labels in biophysics, structural biology, and biomedical research. Resistance of a nitroxide group bearing an unpaired electron to chemical reduction with low-molecular-weight antioxidants and enzymatic systems is of critical importance for these applications. The redox [...] Read more.
Nitroxides are broadly used as molecular probes and labels in biophysics, structural biology, and biomedical research. Resistance of a nitroxide group bearing an unpaired electron to chemical reduction with low-molecular-weight antioxidants and enzymatic systems is of critical importance for these applications. The redox properties of nitroxides are known to depend on the ring size (for cyclic nitroxides) and electronic and steric effects of the substituents. Here, two highly strained nitroxides, 5-(tert-butyl)-5-butyl-2,2-diethyl-3-hydroxypyrrolidin-1-oxyl (4) and 2-(tert-butyl)-2-butyl-5,5-diethyl-3,4-bis(hydroxymethyl)pyrrolidin-1-oxyl (5), were prepared via a reaction of the corresponding 2-tert-butyl-1-pyrroline 1-oxides with butyllithium. Thermal stability and kinetics of reduction of the new nitroxides by ascorbic acid were studied. Nitroxide 5 showed the highest resistance to reduction. Full article
(This article belongs to the Special Issue Stable radicals: synthesis, structure and applications)
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