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Open AccessFeature PaperArticle

Human Serum Albumin Labelled with Sterically-Hindered Nitroxides as Potential MRI Contrast Agents

1
N.N. Vorozhtsov Institute of Organic Chemistry, SB RAS 630090 Novosibirsk, Russia
2
Institute of Chemical Biology and Fundamental Medicine, SB RAS 630090 Novosibirsk, Russia
3
International Tomography Center, SB RAS 630090 Novosibirsk, Russia
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Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
5
Department of Chemistry & Biochemistry, University of Alabama, Tuscaloosa, AL 35487, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Elena G. Bagryanskaya
Molecules 2020, 25(7), 1709; https://doi.org/10.3390/molecules25071709
Received: 17 March 2020 / Revised: 3 April 2020 / Accepted: 7 April 2020 / Published: 8 April 2020
(This article belongs to the Special Issue Stable Radicals: Synthesis, Structure and Applications)
Four albumin-nitroxide conjugates were prepared and tested as metal-free organic radical contrast agents (ORCAs) for magnetic resonance imaging (MRI). Each human serum albumin (HSA) carrier bears multiple nitroxides conjugated via homocysteine thiolactones. These molecular conjugates retain important physical and biological properties of their HSA component, and the resistance of their nitroxide groups to bioreduction was retained or enhanced. The relaxivities are similar for these four conjugates and are much greater than those of their individual components: the HSA or the small nitroxide molecules. This new family of conjugates has excellent prospects for optimization as ORCAs. View Full-Text
Keywords: nitroxide radicals; spin probes; organic radical contrast agents; human serum albumin; homocysteine thiolactone; magnetic resonance imaging nitroxide radicals; spin probes; organic radical contrast agents; human serum albumin; homocysteine thiolactone; magnetic resonance imaging
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Dobrynin, S.; Kutseikin, S.; Morozov, D.; Krumkacheva, O.; Spitsyna, A.; Gatilov, Y.; Silnikov, V.; Angelovski, G.; Bowman, M.K.; Kirilyuk, I.; Chubarov, A. Human Serum Albumin Labelled with Sterically-Hindered Nitroxides as Potential MRI Contrast Agents. Molecules 2020, 25, 1709.

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