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Special Issue "Application of Spectroscopic Sensors in Life Science and Analytical Chemistry"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 30 November 2019

Special Issue Editor

Guest Editor
Dr. Torsten Frosch

1. Leibniz Institute of Photonic Technology, Albert Einstein Strasse 9, D-07745 Jena, Germany
2. Abbe Center of Photonics & Institute of Physical Chemistry, Friedrich Schiller University Jena, D-07745 Jena, Germany
Website | E-Mail
Interests: Raman Spectroscopy and Instrumentation; Gas sensing; Fiber sensing; Chemical Imaging; Pharmaceutical spectroscopy and Biosensing; Elucidation of drug target interactions; environmental monitoring

Special Issue Information

Dear Colleagues,

This Special Issue highlights recent developments in the field of Raman and infrared spectroscopy for applications in life science and analytical chemistry. Vibrational spectroscopy offers an extremely high chemical selectivity with no need for labeling or extensive sample preparation. Recent developments towards signal enhancement, miniaturization and robustness pave the way for plenty new applications in various interdisciplinary topics. Exciting fields for in-line analysis, point-of-care and onsite application are biomedical diagnostic, environmental monitoring, process analysis, investigation of pharmaceuticals, food analysis, materials development and many others.

In order to give an update of recent progresses in technique improvements and new applications, you are kindly invited to submit your original articles or reviews of your work.

Dr. Torsten Frosch
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • raman spectroscopy
  • infrared spectroscopy
  • analytical chemistry
  • life science
  • chemical sensing
  • environmental monitoring
  • biomedical diagnostics
  • chemical imaging
  • food analysis
  • pharmaceutical analysis
  • process monitoring

Published Papers (2 papers)

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Research

Open AccessArticle Rapid and Integrated Quality Assessment of Organic-Inorganic Composite Herbs by FTIR Spectroscopy—Global Chemical Fingerprints Identification and Multiple Marker Components Quantification of Indigo Naturalis (Qing Dai)
Molecules 2018, 23(11), 2743; https://doi.org/10.3390/molecules23112743
Received: 8 October 2018 / Revised: 22 October 2018 / Accepted: 23 October 2018 / Published: 24 October 2018
PDF Full-text (2220 KB) | HTML Full-text | XML Full-text
Abstract
This research aimed to develop an FTIR-based method for rapid and low-cost integrated quality assessment of organic-inorganic composite herbs, which are kinds of herbs composed of both organic and inorganic active ingredients or matrix components. A two-step quality assessment route was designed and
[...] Read more.
This research aimed to develop an FTIR-based method for rapid and low-cost integrated quality assessment of organic-inorganic composite herbs, which are kinds of herbs composed of both organic and inorganic active ingredients or matrix components. A two-step quality assessment route was designed and verified using the example of Indigo Naturalis (Qing Dai). First, the FTIR spectra were used as global chemical fingerprints to identify the true and fake samples. Next, the contents of the organic and inorganic marker components were estimated by FTIR quantification models to assess the quality of the true samples. Using the above approaches, all the 56 true samples and five fake samples of Indigo Naturalis could be identified correctly by the correlation threshold of the FTIR chemical fingerprints. Furthermore, the FTIR calibration models provided an accurate estimation of the contents of marker components with respect to HPLC and inductively coupled plasma optical emission spectrometry (ICP-OES). The coefficients of determination (R2) for the independent validation of indigo, indirubin, and calcium were 0.977, 0.983, and 0.971, respectively. Meanwhile, the mean relative errors (MRE) for the independent validation of indigo, indirubin, and calcium were 2.2%, 2.4%, and 1.8%, respectively. In conclusion, this research shows the potential of FTIR spectroscopy for the rapid and integrated quality assessment of organic-inorganic composite herbs in both chemical fingerprints identification and marker components quantification. Full article
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Graphical abstract

Open AccessArticle Determination of Total Polysaccharides and Total Flavonoids in Chrysanthemum morifolium Using Near-Infrared Hyperspectral Imaging and Multivariate Analysis
Molecules 2018, 23(9), 2395; https://doi.org/10.3390/molecules23092395
Received: 3 September 2018 / Revised: 16 September 2018 / Accepted: 18 September 2018 / Published: 19 September 2018
Cited by 1 | PDF Full-text (1765 KB) | HTML Full-text | XML Full-text
Abstract
The rapid and nondestructive determination of active compositions in Chrysanthemum morifolium (Hangbaiju) is of great value for producers and consumers. Hyperspectral imaging as a rapid and nondestructive technique was used to determine total polysaccharides and total flavonoids content in Chrysanthemum morifolium. Hyperspectral
[...] Read more.
The rapid and nondestructive determination of active compositions in Chrysanthemum morifolium (Hangbaiju) is of great value for producers and consumers. Hyperspectral imaging as a rapid and nondestructive technique was used to determine total polysaccharides and total flavonoids content in Chrysanthemum morifolium. Hyperspectral images of different sizes of Chrysanthemum morifolium flowers were acquired. Pixel-wise spectra within all samples were preprocessed by wavelet transform (WT) followed by standard normal variate (SNV). Partial least squares (PLS) and least squares-support vector machine (LS-SVM) were used to build prediction models using sample average spectra calculated by preprocessed pixel-wise spectra. The LS-SVM model performed better than the PLS models, with the determination of the coefficient of calibration (R2c) and prediction (R2p) being over 0.90 and the residual predictive deviation (RPD) being over 3 for total polysaccharides and total flavonoids content prediction. Prediction maps of total polysaccharides and total flavonoids content in Chrysanthemum morifolium flowers were successfully obtained by LS-SVM models, which exhibited the best performances. The overall results showed that hyperspectral imaging was a promising technique for the rapid and accurate determination of active ingredients in Chrysanthemum morifolium, indicating the great potential to develop an online system for the quality determination of Chrysanthemum morifolium. Full article
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