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Infrared and 2-Dimensional Correlation Spectroscopy Study of the Effect of CH3NH3PbI3 and CH3NH3SnI3 Photovoltaic Perovskites on Eukaryotic Cells

1
Department of Physical Chemistry and Electrochemistry, Faculty of Chemistry, Jagiellonian University, PL-30387 Kraków, Poland
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Laboratory of Physics of Complex Matter, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
3
POMAM Lab, Institut de Chimie de Strasbourg UMR 7177, CNRS/UdS. 4 rue Blaise Pascal, CS 90032, 67081 Strasbourg CEDEX, France
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(2), 336; https://doi.org/10.3390/molecules25020336
Received: 19 December 2019 / Revised: 3 January 2020 / Accepted: 9 January 2020 / Published: 14 January 2020
We studied the effect of the exposure of human A549 and SH-SY5Y cell lines to aqueous solutions of organic/inorganic halide perovskites CH3NH3PbI3 (MAPbI3) and CH3NH3SnI3 (MASnI3) at the molecular level by using Fourier transform infrared microspectroscopy. We monitored the infrared spectra of some cells over a few days following exposure to the metals and observed the spectroscopic changes dominated by the appearance of a strong band at 1627 cm−1. We used Infrared (IR) mapping to show that this change was associated with the cell itself or the cellular membrane. It is unclear whether the appearance of the 1627 cm−1 band and heavy metal exposure are related by a direct causal relationship. The spectroscopic response of exposure to MAPbI3 and MASnI3 was similar, indicating that it may arise from a general cellular response to stressful environmental conditions. We used 2D correlation spectroscopy (2DCOS) analysis to interpret spectroscopic changes. In a novel application of the method, we demonstrated the viability of 2DCOS for band assignment in spatially resolved spectra. We assigned the 1627 cm−1 band to the accumulation of an abundant amide or amine containing compound, while ruling out other hypotheses. We propose a few tentative assignments to specific biomolecules or classes of biomolecules, although additional biochemical characterization will be necessary to confirm such assignments. View Full-Text
Keywords: infrared spectroscopy; infrared microscopy; 2DCOS; perovskite; amyloid infrared spectroscopy; infrared microscopy; 2DCOS; perovskite; amyloid
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Quaroni, L.; Benmessaoud, I.; Vileno, B.; Horváth, E.; Forró, L. Infrared and 2-Dimensional Correlation Spectroscopy Study of the Effect of CH3NH3PbI3 and CH3NH3SnI3 Photovoltaic Perovskites on Eukaryotic Cells. Molecules 2020, 25, 336.

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