Design, Synthesis and Structure-Activity Relationship of Small-Molecule Inhibitors
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 14830
Special Issue Editor
Special Issue Information
Dear Colleagues,
Small molecule inhibitors are a class of organic molecules or natural products which can bind to target proteins and reduce their biological activity. Currently, they are still the main component of most small molecule drugs in clinic. In addition, they are often used as tools in biological and pharmacological research to understand the functions of proteins and their role in normal physiology and disease pathology. Small molecule inhibitors play a significant role in medical chemistry and related subjects of pharmacy. Therefore, researchers from the pharmaceutical field and from academia always focus their efforts on identifying and developing novel and valuable small molecule inhibitors. Discovery and optimization of novel small molecule inhibitors through rational design strategies are very interesting and full of challenges and will provide more information and experience to related researchers of medicinal chemistry.
This Special Issue will focus on the latest processes and strategies in the field of designing and optimizing small molecule inhibitors. Scientists from related research fields around the world are cordially invited to contribute original research articles or reviews to this Special Issue of Molecules and present their latest work on the design, synthesis, and structure–activity relationship of small-molecule inhibitors, including selective or multiple-target small molecule inhibitors for targeting different enzymes or signal pathways, etc.
Dr. Qihua Zhu
Guest Editor
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Keywords
- small molecule inhibitors
- drug design
- structure–activity relationship (SAR)
- selective inhibitors
- multiple target inhibitors
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