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Special Issue "Selective and Sensitive Detection of Biological and Chemical Species"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 30 September 2019

Special Issue Editor

Guest Editor
Prof. Dr. Yu Lei

Department of Chemical and Biomolecular Engineering, Graduate Faculty of Department of Biomedical Engineering, University of Connecticut, 191 Auditorium Road, Storrs, CT 06269, USA
Website | E-Mail
Interests: biosensor; chemical sensor; bionanotechnology; environmental biotechnology; nanomaterials-based high temperature gas sensing; microfluidic-based (bio)sensor

Special Issue Information

Dear Colleagues,

The detection of biological and chemical species plays an important role in various applications, including public health, food safety, environmental monitoring, homeland security, and energy. To improve the sensing performance (e.g., sensitivity, selectivity, stability) in molecules detection, various sensing materials in nanoscale and novel sensing strategies have been employed. In particular, recent developments in biotechnology and nanotechnology have led to witnessing the detection of biological and chemical species with significantly enhanced sensing performance. Therefore, this Special Issue will highlight recent advances of science and technologies in the detection of chemical and biological species, ranging from chemistry and chemical and biomedical engineering to environmental engineering, material science and engineering, energy sustainability, etc.

In this Special Issue, we solicit review articles and original research papers covering all aspects of the detection of biological and chemical species. Topics of primary interest include but are not limited to all kinds of chemical and biological sensors based on various sensing elements (biological, organic, and inorganic materials in macro-, micro- and nanoscale). Novel sensing technologies and platforms with enhanced sensitivity and selectivity are also welcome.

Prof. Dr. Yu Lei
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Chemical sensor
  • Biosensor
  • Nanotechnology
  • Biotechnology
  • Chemical species
  • Biological species

Published Papers (1 paper)

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Open AccessArticle
Synthesis of Fluorescent Carbon Dots as Selective and Sensitive Probes for Cupric Ions and Cell Imaging
Molecules 2019, 24(9), 1785; https://doi.org/10.3390/molecules24091785
Received: 26 March 2019 / Revised: 6 May 2019 / Accepted: 8 May 2019 / Published: 8 May 2019
PDF Full-text (5075 KB) | HTML Full-text | XML Full-text | Supplementary Files
A novel sensing system has been designed for the detection of cupric ions. It is based on the quenched fluorescence signal of carbon dots (CDs), which were carbonized from poly(vinylpyrrolidone) (PVP) and L-Cysteine (CYS). Cupric ions interact with the nitrogen and sulfur atoms [...] Read more.
A novel sensing system has been designed for the detection of cupric ions. It is based on the quenched fluorescence signal of carbon dots (CDs), which were carbonized from poly(vinylpyrrolidone) (PVP) and L-Cysteine (CYS). Cupric ions interact with the nitrogen and sulfur atoms on surface of the CDs to form an absorbed complex; this results in strong quenching of the fluorescence of the CDs via a fast metal-to-ligand binding affinity. The synthesized water-soluble CDs also exhibited a quantum yield of 7.6%, with favorable photoluminescent properties and good photostability. The fluorescence intensity of the CDs was very stable in high ionic strength (up to 1.0 M NaCl) and over a wide range of pH levels (2.0–12.0). This facile method can therefore develop a sensor that offers reliable, fast, and selective detection of cupric ions with a detection limit down to 0.15 μM and a linear range from 0.5 to 7.0 μM (R2 = 0.980). The CDs were used for cell imaging, observed that they were low toxicity to Tramp C1 cells and exhibited blue and green and red fluorescence under a fluorescence microscope. In summary, the CDs exhibited excellent fluorescence properties, and could be applied to the selective and sensitive detection of cupric ion and multicolor cell imaging. Full article
(This article belongs to the Special Issue Selective and Sensitive Detection of Biological and Chemical Species)

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