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Open AccessReview

The Asymmetric A3(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines

Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, China
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Academic Editor: Cimarelli Cristina
Molecules 2019, 24(7), 1216; https://doi.org/10.3390/molecules24071216
Received: 28 February 2019 / Revised: 22 March 2019 / Accepted: 27 March 2019 / Published: 28 March 2019
(This article belongs to the Special Issue Multicomponent Reactions)
The recent developments in asymmetric A3 (aldehyde–alkyne–amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction of nitrogen-containing chiral building blocks. View Full-Text
Keywords: aldehydes; alkynes; amines; asymmetric catalysis; copper; multicomponent reactions; nitrogen heterocycles aldehydes; alkynes; amines; asymmetric catalysis; copper; multicomponent reactions; nitrogen heterocycles
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Mo, J.-N.; Su, J.; Zhao, J. The Asymmetric A3(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines. Molecules 2019, 24, 1216.

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