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Special Issue "Fabulous Fluorine in Organic and Medicinal Chemistry"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 15 December 2018

Special Issue Editor

Guest Editor
Prof. Dr. Norio Shibata

(1) Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology Gokiso, Showa-ku, Nagoya 466-8555, Japan
(2) Department of Life Science and Applied Chemistry, Nagoya Institute of Technology Gokiso, Showa-ku, Nagoya 466-8555, Japan
(3) Institute of Advanced Fluorine-Containing Materials, Zhejiang Normal University, 688 Yingbin Avenue, 321004 Jinhua, China
Website | E-Mail
Phone: +81-52-735-7543
Interests: fluorine chemistry; synthetic chemistry; asymmetric synthesis; medicinal chemistry; C-F bond activation; organosulfur compounds; organo halogen compounds

Special Issue Information

Dear Colleagues,

Organofluorine compounds represent one of the most valuable drug candidates in medicinal chemistry. Fluorine and fluoro-functional groups are of crucial importance in the context of agrochemical, pharmaceutical, and material science, as the unique nature of fluorine strongly affects the chemical properties of the products. Various type of synthetic methodology have been reported for this purpose, however, there are still many kinds of fluorinated and fluoro-functionalized compounds that are difficult to be synthesized. Interestingly, this situation has been altered rapidly, due to the recent powerful technologies for organic reactions. In the 21st century, novel technologies for organic reactions have emerged such as metal-catalyzed bond formation, bond-activation, metal- or organo-catalyzed photoredox reactions, and microflow-reactor/flow technology. These innovations have dramatically affected the situation of synthetic organofluorine chemistry. Thus, this Special Issue is dedicated to the state-of-the-art of organofluorine chemistry. I am, therefore, looking forward to receiving timeless research articles, communications and reviews detailing the remarkable progress of all aspects of organofluorine chemistry. Researches covered widely in this special issue include, fluorinations, trifluoromethylations, fluoro-functionalizations (SCF3, OCF3, SO2CF3, SF5, etc.), cross-couplings, asymmetric transformations, C-F bond activations, flow-technologies and fundamental studies on reactivity of organofluorine compounds. The issue also covers not only synthetic fluorine chemistry, but also bio- and medicinal fluorine chemistry. In addition, it is a perfect time to invite scientists to submit original contributions to the fluorine-dedicated Special Issue in 2018, since there are several international conference dedicated to fluorine in 2018, such as Nanjing Fluorine Days (May, 2018, Nanjing, China) and 22nd International Symposium on Fluorine Chemistry (July 2018, Oxford, UK), for examples. I hope you will join us in this Special Issue.

Prof. Dr. Norio Norio Shibata
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • fluorination
  • fluoroalkylation
  • fluoro-functionalization
  • C-F bond activation
  • synthetic fluorine chemistry
  • medicinal fluorine chemistry
  • catalyst

Published Papers

This special issue is now open for submission.
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