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General, Practical and Selective Oxidation Protocol for CF3S into CF3S(O) Group

1
Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmans’ka Str. 5, 02094 Kyiv, Ukraine
2
Bâtiment Lavoisier, Université de Versailles-Saint-Quentin, 45 avenue des Etats-Unis, 78035 Versailles, France
3
Enamine Ltd, A. Matrosova str. 23, Kiev 01103, Ukraine
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(7), 1249; https://doi.org/10.3390/molecules24071249
Received: 14 March 2019 / Revised: 25 March 2019 / Accepted: 27 March 2019 / Published: 30 March 2019
(This article belongs to the Special Issue Fabulous Fluorine in Organic and Medicinal Chemistry)
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Abstract

A simple and efficient protocol for the oxidation of trifluoromethyl, mono- and difluoromethyl sulfides to the corresponding sulfoxides without over-oxidation to sulfones, using TFPAA prepared in situ from trifluoroacetic acid and 15% H2O2 aqueous solution was developed. The methodology is suitable for a wide range of aromatic and aliphatic substrates in milligram and multigram scales. View Full-Text
Keywords: trifluoromethylsulfides; trifluoromethylsulfoxides; oxidation; trifluoroperacetic acid; dihydrogen peroxide trifluoromethylsulfides; trifluoromethylsulfoxides; oxidation; trifluoroperacetic acid; dihydrogen peroxide
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Sokolenko, L.V.; Orlova, R.K.; Filatov, A.A.; Yagupolskii, Y.L.; Magnier, E.; Pégot, B.; Diter, P. General, Practical and Selective Oxidation Protocol for CF3S into CF3S(O) Group. Molecules 2019, 24, 1249.

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