Next Article in Journal
Continuous Gradient Temperature Raman Spectroscopy of Fish Oils Provides Detailed Vibrational Analysis and Rapid, Nondestructive Graphical Product Authentication
Next Article in Special Issue
Asymmetric Electrophilic Difluoromethylthiolation of Indanone-Based β-Keto Esters Using Difluoromethanesulfonyl Hypervalent Iodonium Ylides
Previous Article in Journal
Formation and Characterization of Lactoferrin-Hyaluronic Acid Conjugates and Their Effects on the Storage Stability of Sesamol Emulsions
Open AccessBrief Report

Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate

1
Division of Molecular Science, Graduate School of Science and Technology, 1-5-1, Tenjin-cho, Kiryu, Gunma 376-8515, Japan
2
Department of Chemistry, Graduate School of Science, Kobe University, Nada-ku, Kobe 657-8501, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Norio Shibata
Molecules 2018, 23(12), 3292; https://doi.org/10.3390/molecules23123292
Received: 17 November 2018 / Revised: 3 December 2018 / Accepted: 10 December 2018 / Published: 11 December 2018
(This article belongs to the Special Issue Fabulous Fluorine in Organic and Medicinal Chemistry)
A convenient and effective route for the synthesis of aryl(difluoromethyl)phosphonates has been developed based on cross-coupling reactions. Upon treatment with a stoichiometric amount (or a catalytic amount in some cases) of CuI and CsF, aryl iodides reacted smoothly with (silyldifluoromethyl)phosphonates to give the corresponding aryl(difluoromethyl)phosphonates in good yields. View Full-Text
Keywords: phosphonates; difluoromethyl; cross-coupling; copper; silicon phosphonates; difluoromethyl; cross-coupling; copper; silicon
Show Figures

Graphical abstract

MDPI and ACS Style

Komoda, K.; Iwamoto, R.; Kasumi, M.; Amii, H. Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate. Molecules 2018, 23, 3292.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop