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Molecules
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Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices...
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Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis II

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 13138

Special Issue Editors

Dr. Marcello Locatelli

E-Mail Website
Guest Editor
Department of Pharmacy, University “G. d\'Annunzio” of Chieti and Pescara, Chieti, Italy
Interests: innovative (micro)extraction procedures; hyphenated instrument configurations; bioactive compounds; characterization; fingerprints; method validation; HPLC; mass spectrometry; biological matrices; chromatography; analytical chemistry; sample preparation; green analytical methodologies
Special Issues, Collections and Topics in MDPI journals
Dr. Angela Tartaglia

E-Mail Website
Guest Editor
Department of Pharmacy, University “G. d'Annunzio” of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Interests: sample preparation; biological matrices; bioanalysis; microextraction procedures; separation techniques; chromatography
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Abuzar Kabir

E-Mail Website
Guest Editor
International Forensic Research Institute, Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA
Interests: chromatographic stationary phases; substrate-free solid-phase extraction sorbents; molecular imprinting technology; sorbents for environmental pollution remediation; miniaturized sample preparation devices; field deployable sample preparation technology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Dora Melucci

E-Mail Website
Guest Editor
Department of Chemistry “Giacomo Ciamician”, Alma Mater Studiorum University of Bologna, Via Selmi 2, I-40126 Bologna, Italy
Interests: chemometrics; environmental chemistry; forensics; food chemistry; pharmaceutics
Special Issues, Collections and Topics in MDPI journals
Dr. Roberta Risoluti

E-Mail Website
Guest Editor
Department of Chemistry, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Interests: chemometrics; forensic analysis; microNIR spectroscopy; thermal analysis; clinical and biomedical applications
Special Issues, Collections and Topics in MDPI journals
Dr. Stefano Materazzi

E-Mail Website
Guest Editor
Department of Chemistry, University "Sapienza" of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Interests: hyphenated techniques; evolved gas analysis; microNIR spectroscopy; forensic chemistry; thermal analysis; drug of abuse; food analysis

Special Issue Information

Dear Colleagues,

Innovative analytical instrument configurations are needed to fully characterize xenobiotics and biologically active principles. Nowadays analytical procedures allow to obtain a much closer accuracy (precision and trueness), and consequently correct information about these compounds, the composition of a complex sample, the physicochemical properties, etc. In recent years, new systems have been developed and applied in several fields, such as environmental, biological, forensic, pharmaceutical, and alimentary, which allow scientists to acquire relevant information even when complex matrices are analyzed.

This Special Issue will highlight and describe the latest improvements in instrument configurations, techniques developed, and particularly, innovative statistical approaches applied to analyze the data.

Greater attention will be given to recent developments in sample preparation and extraction techniques, modern detection techniques, and statistical approaches (for both data elaboration and the planning and design of experiments), all with the main target to improve the sensitivity and the selectivity of the proposed method, eliminate false information, search outliers, etc.

Deadlines

  •  Abstract submission: June 2020
  •  Paper submission: 31 July 2020
  •  Revision (Reviewer): end of July 2020
  •  Revised version: end of August 2020
  •  Final proof: end of September 2020

This Special Issue is supported by the Sample Preparation Task Force and Network, of the European Chemical Society-Division of Analytical Chemistry (https://www.sampleprep.tuc.gr/en/home/).

Prof. Dr. Marcello Locatelli
Dr. Angela Tartaglia
Dr. Abuzar Kabir
Prof. Dora Melucci
Dr. Roberta Risoluti
Dr. Stefano Materazzi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hyphenated techniques and instrument configurations;
  • (micro)extraction procedures;
  • food and food supplements analyses;
  • medicinal plants and fungi;
  • complex matrices;
  • biological analyses;
  • chemometric approaches

Published Papers (4 papers)

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Research

13 pages, 1888 KiB  
Article
Comparison on Reduction of VOCs Emissions from Radiata Pine (Pinus Radiata D. Don) between Sodium Bicarbonate and Ozone Treatments
by Ye Qin, Fei Qi, Zhiping Wang, Xianbao Cheng, Botao Li, Anmin Huang and Ru Liu
Molecules 2020, 25(3), 471; https://doi.org/10.3390/molecules25030471 - 22 Jan 2020
Cited by 4 | Viewed by 2597
Abstract
Volatile organic compounds (VOCs) in wood furniture are an important factor that affects indoor air quality. In this study, radiata pine (Pinus radiata D. Don) was treated with sodium bicarbonate and ozone aqueous solution to reduce the VOC contents without sacrificing mechanical [...] Read more.
Volatile organic compounds (VOCs) in wood furniture are an important factor that affects indoor air quality. In this study, radiata pine (Pinus radiata D. Don) was treated with sodium bicarbonate and ozone aqueous solution to reduce the VOC contents without sacrificing mechanical properties. The VOCs of radiata pine were identified by gas chromatography-mass spectrometry (GC-MS), and the functional group changes of wood samples were characterized by Fourier-transform infrared spectroscopy (FTIR). The results showed that the main VOCs of radiata pine include alkenes, aldehydes, and esters. The sodium bicarbonate and ozone treatments almost eliminated the VOC contents of radiata pine. The two treatments mentioned above had little effect on compressive strength and surface color of radiata pine. Full article
(This article belongs to the Special Issue Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis II)
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16 pages, 3289 KiB  
Article
Optimization of Ultrasonic Flavonoid Extraction from Saussurea involucrate, and the Ability of Flavonoids to Block Melanin Deposition in Human Melanocytes
by Chun-Yan Dai, Pei-Ran Liao, Ming-Zhuo Zhao, Chao Gong, Yue Dang, Yuan Qu and Li-Sha Qiu
Molecules 2020, 25(2), 313; https://doi.org/10.3390/molecules25020313 - 13 Jan 2020
Cited by 12 | Viewed by 3057
Abstract
(1) Background: Flavonoids are the primary medicinal ingredient of Saussurea involucrate, which have significant antioxidant capacity. Optimizing the extraction of Saussurea involucrate flavonoids (SIFs) and exploring the ability to block melanin deposition caused by reactive oxygen can greatly promote the development of [...] Read more.
(1) Background: Flavonoids are the primary medicinal ingredient of Saussurea involucrate, which have significant antioxidant capacity. Optimizing the extraction of Saussurea involucrate flavonoids (SIFs) and exploring the ability to block melanin deposition caused by reactive oxygen can greatly promote the development of S. involucrate whitening products. (2) Methods: Ultrasonic extraction process was optimized using the Box–Behnken design (BBD) and response surface methodology (RSM). Then, the effect of SIFs on antioxidant activity and anti-deposition of melanin, and genes related to the melanin synthesis are studied. (3) Results: The optimal extraction procedures are as follows: the extraction time, ethanol content, and solvent ratio (v/w) are 64 min, 54%, and 54:1, respectively. The reducing activity and scavenging rates of 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, and ABTS+ were promoted as more S. involucrate flavonoid extract was added. The SIFs extract induced a decrease in the melanin synthesis by inhibiting the human melanoma A375 cell tyrosinase activity. SIFs also depress expression of melanin synthesis related genes. (4) Conclusions: the highest SIFs content was obtained by using 54% ethanol and 54:1 solvent ratio (v/w) for 64 min. The extract of SIFs exhibited good ability of antioxidant and anti-deposition of melanin in human melanocytes. Full article
(This article belongs to the Special Issue Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis II)
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15 pages, 3098 KiB  
Article
Analytical Methodology for Trace Determination of Propoxur and Fenitrothion Pesticide Residues by Decanoic Acid Modified Magnetic Nanoparticles
by Amine Gizem Canlı, Bilge Sürücü, Halil İbrahim Ulusoy, Erkan Yılmaz, Abuzar Kabir and Marcello Locatelli
Molecules 2019, 24(24), 4621; https://doi.org/10.3390/molecules24244621 - 17 Dec 2019
Cited by 18 | Viewed by 4064
Abstract
A sensitive, rapid, reliable, and easily applicable method based on magnetic solid phase extraction (MSPE) combined with HPLC-PDA was developed for monitoring propoxur (PRO) and fenitrothion (FEN) pesticides in environmental water samples. The effect of major experimental variables on the extraction efficiency of [...] Read more.
A sensitive, rapid, reliable, and easily applicable method based on magnetic solid phase extraction (MSPE) combined with HPLC-PDA was developed for monitoring propoxur (PRO) and fenitrothion (FEN) pesticides in environmental water samples. The effect of major experimental variables on the extraction efficiency of both the pesticides was investigated and optimized systematically. For this purpose, a new magnetic material containing decanoic acid on the surface of particles was synthesized and characterized by XRD, FT-IR, SEM, EDX, and TGA analysis in detail. The simultaneous determination of pesticide molecules was carried out by using a Luna Omega C18 column, isocratic elution of acetonitrile (ACN): Water (70:30 v/v) with a flow rate of 1.2 mL min−1. After MSPE, the linear range for pesticide molecules (r2 > 0.9982) was obtained in the range of 5–800 and 10–800 ng mL−1, respectively. The limit of detections (LOD) are 1.43 and 4.71 ng mL−1 for PRO and FEN, respectively while RSDs % are below 3.5%. The applicability of the proposed method in four different environmental samples were also investigated using a standard addition-recovery procedure. Average recoveries at two spiking levels were over the range of 91.3–102.5% with RSD < 5.0% (n = 3). The obtained results show that decanoic acid grafted magnetic particles in MSPE combined with HPLC-PDA is a fast and simple method for the determination of PRO and FEN in environmental water samples. Full article
(This article belongs to the Special Issue Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis II)
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12 pages, 1525 KiB  
Article
Graphene Oxide/Polyethylene Glycol-Stick for Thin Film Microextraction of β-Blockers from Human Oral Fluid by Liquid Chromatography-Tandem Mass Spectrometry
by Hanieh Karimiyan, Mohammad Reza Hadjmohammadi, Karthik Laxman Kunjali, Mohammad Mahdi Moein, Joydeep Dutta and Mohamed Abdel-Rehim
Molecules 2019, 24(20), 3664; https://doi.org/10.3390/molecules24203664 - 11 Oct 2019
Cited by 9 | Viewed by 2631
Abstract
A wooden stick coated with a novel graphene-based nanocomposite (Graphene oxide/polyethylene glycol (GO/PEG)) is introduced and investigated for its efficacy in solid phase microextraction techniques. The GO/PEG-stick was prepared and subsequently applied for the extraction of β-blockers, acebutolol, and metoprolol in human oral [...] Read more.
A wooden stick coated with a novel graphene-based nanocomposite (Graphene oxide/polyethylene glycol (GO/PEG)) is introduced and investigated for its efficacy in solid phase microextraction techniques. The GO/PEG-stick was prepared and subsequently applied for the extraction of β-blockers, acebutolol, and metoprolol in human oral fluid samples, which were subsequently detected by liquid chromatography tandem mass spectrometry (LC-MS/MS). Experimental parameters affecting the extraction protocol including sample pH, extraction time, desorption time, appropriate desorption solvent, and salt addition were optimized. Method validation for the detection from oral fluid samples was performed following FDA (Food and Drug Administration) guidelines on bioanalytical method validation. Calibration curves ranging from 5.0 to 2000 nmol L−1 for acebutolol and 25.0 to 2000 nmol L−1 for metoprolol were used. The values for the coefficient of determination (R2) were found to be 0.998 and 0.996 (n = 3) for acebutolol and metoprolol, respectively. The recovery of analytes during extraction was 80.0% for acebutolol and 62.0% for metoprolol, respectively. The limit of detections (LODs) were 1.25, 8.00 nmol L−1 for acebutolol and metoprolol and the lower limit of quantifications (LLOQ) were 5.00 nmol L−1 for acebutolol and 25.0 nmol L−1 for metoprolol. Validation experiments conducted with quality control (QC) samples demonstrated method accuracy between 80.0% to 97.0% for acebutolol and from 95.0% to 109.0% for metoprolol. The inter-day precision for QC samples ranged from 3.6% to 12.9% for acebutolol and 9.5% to 11.3% for metoprolol. Additionally, the GO/PEG-stick was demonstrated to be reusable, with the same stick observed to be viable for more than 10 extractions from oral fluid samples. Full article
(This article belongs to the Special Issue Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis II)
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