Special Issue "Compound Management"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 May 2011).
Interests: acoustic dispensing; liquid handling; automation; high throughput screening; automated compound storage; DMSO storage conditions; long term storage effects; efficient determination of compound quality/purity/solubilization/concentration; optimal compound collection size
Compound management has become a multi-disciplinary field encompassing many facets of chemistry, engineering, software development, and database administration. Multi-million dollar facilities have been constructed to warehouse and distribute compounds globally with the goal of quick turnaround. In some cases best practices regarding storage of compounds in DMSO solution have been rationalized based on the need to meet the ever present demand of compound for HTS screening and follow-up.
Compound management, though, is no longer solely in the purview of big pharma. The varieties of economical, commercially available screening libraries are widespread. Liquid and plate handling instrumentation are more robust than ever, and the capital needed to procure them diminishes as newer technologies enter the market. Compound management at this scale is allowing more researchers to explore novel chemical space in a more focused manner.
This special issue will focus on topics in compound management within the scope of Molecules.
- acoustic dispensing
- compound management of natural products
- orthogonal pooled screening strategies
- screening for synergistic effects
- DMSO storage conditions
- siRNA library management
- efficient determination of compound quality, purity, solubility and concentration