Huisgen 3+n Dipolar Cycloaddition Reactions: An Accessible and Useful Tool in Modern Organic and Heterocycle Synthesis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 27997
Special Issue Editor
Interests: heterocycles; medicinal chemistry; anticancer; antituberculosis; microwave; ultrasounds; organic synthesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Organic compounds, especially heterocycle derivatives, have been reported as highly valuable materials in medicine and pharmacy, opto-electronics, agriculture, and numerous other fields. One of the most challenging issues in fine organic and heterocycle chemistry remains the synthesis of such systems. The Huisgen 3+n dipolar cycloaddition reactions of ylides to various dipolarophiles represents, in this respect, a useful and powerful approach which allow for the construction of new heterocycle derivatives that are otherwise very difficult or impossible to obtain. On the other hand, Huisgen 3+n dipolar cycloaddition has given rise to interesting practical and theoretical problems of stereochemistry, regiochemistry, chorochemistry, etc., which are still waiting to be resolved.
The aim of this Special Issue is to provide a platform to present the latest developments in the Huisgen 3+n dipolar cycloaddition reactions in fine organic and heterocycle synthesis, focused on the cycloaddition reactions of ylides to various dipolarophiles as well as to the applications of the obtained compounds in medicine and pharmacy, opto-electronics, and agriculture, to name but a few.
Prof. Dr. Ionel Mangalagiu
Guest Editor
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Keywords
- Huisgen 3+n dipolar cycloadditions
- organic and heterocycles compounds
- ylides
- dipolarophiles
- stereochemistry
- regiochemistry
- chorochemistry
- quantum mechanics approaches (HOMO and LUMO orbital, etc.)
- applications (medicine and pharmacy, opto-electronics, agriculture, etc.)
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