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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Parallel Palladium-Catalyzed Synthesis of Carboxylic Acids from Aryl Iodides, Bromides, and Vinyl Triflates Using Acetic Anhydride and Formate Anion as an External Condensed Source of Carbon Monoxide

by
Antonia Iazzetti
1,2,
Giancarlo Fabrizi
3,
Yuri Gazzilli
3,
Antonella Goggiamani
3,*,
Federico Marrone
3,
Chen Shen
3 and
Roberta Zoppoli
3
1
Dipartimento di Scienze Biotecnologiche di base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, L. go Francesco Vito 1, 00168 Rome, Italy
2
Policlinico Universitario ‘A. Gemelli’ Foundation-IRCCS, 00168 Rome, Italy
3
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P. le A. Moro 5, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
Molecules 2025, 30(15), 3298; https://doi.org/10.3390/molecules30153298
Submission received: 27 June 2025 / Revised: 16 July 2025 / Accepted: 5 August 2025 / Published: 6 August 2025
(This article belongs to the Special Issue 30th Anniversary of Molecules—Recent Advances in Organic Chemistry)
Versions Notes

Abstract

Aryl iodides, bromides and vinyl-triflates are usually converted in high to excellent yields into the corresponding carboxylic acids through a parallel palladium-catalyzed hydroxycarbonylation using lithium formate and acetic anhydride as external condensed source of carbon monoxide.
Keywords: palladium catalysis; carbon monoxide; carboxylic acid; combinatorial chemistry palladium catalysis; carbon monoxide; carboxylic acid; combinatorial chemistry

Share and Cite

MDPI and ACS Style

Iazzetti, A.; Fabrizi, G.; Gazzilli, Y.; Goggiamani, A.; Marrone, F.; Shen, C.; Zoppoli, R. Parallel Palladium-Catalyzed Synthesis of Carboxylic Acids from Aryl Iodides, Bromides, and Vinyl Triflates Using Acetic Anhydride and Formate Anion as an External Condensed Source of Carbon Monoxide. Molecules 2025, 30, 3298. https://doi.org/10.3390/molecules30153298

AMA Style

Iazzetti A, Fabrizi G, Gazzilli Y, Goggiamani A, Marrone F, Shen C, Zoppoli R. Parallel Palladium-Catalyzed Synthesis of Carboxylic Acids from Aryl Iodides, Bromides, and Vinyl Triflates Using Acetic Anhydride and Formate Anion as an External Condensed Source of Carbon Monoxide. Molecules. 2025; 30(15):3298. https://doi.org/10.3390/molecules30153298

Chicago/Turabian Style

Iazzetti, Antonia, Giancarlo Fabrizi, Yuri Gazzilli, Antonella Goggiamani, Federico Marrone, Chen Shen, and Roberta Zoppoli. 2025. "Parallel Palladium-Catalyzed Synthesis of Carboxylic Acids from Aryl Iodides, Bromides, and Vinyl Triflates Using Acetic Anhydride and Formate Anion as an External Condensed Source of Carbon Monoxide" Molecules 30, no. 15: 3298. https://doi.org/10.3390/molecules30153298

APA Style

Iazzetti, A., Fabrizi, G., Gazzilli, Y., Goggiamani, A., Marrone, F., Shen, C., & Zoppoli, R. (2025). Parallel Palladium-Catalyzed Synthesis of Carboxylic Acids from Aryl Iodides, Bromides, and Vinyl Triflates Using Acetic Anhydride and Formate Anion as an External Condensed Source of Carbon Monoxide. Molecules, 30(15), 3298. https://doi.org/10.3390/molecules30153298

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