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Metabolite Profiling: A Tool for the Biochemical Characterisation of Mycobacterium sp.

School of Biological Sciences, Royal Holloway University of London, Egham Hill, Egham TW20 0EX, UK
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Microorganisms 2019, 7(5), 148; https://doi.org/10.3390/microorganisms7050148
Received: 4 April 2019 / Revised: 13 May 2019 / Accepted: 25 May 2019 / Published: 25 May 2019
Over the last decades, the prevalence of drug-resistance in Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, has increased. These findings have rekindled interest in elucidating the unique adaptive molecular and biochemistry physiology of Mycobacterium. The use of metabolite profiling independently or in combination with other levels of “-omic” analyses has proven an effective approach to elucidate key physiological/biochemical mechanisms associated with Mtb throughout infection. The following review discusses the use of metabolite profiling in the study of tuberculosis, future approaches, and the technical and logistical limitations of the methodology. View Full-Text
Keywords: mycobacteria; metabolomics; anti-TB drugs mycobacteria; metabolomics; anti-TB drugs
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Drapal, M.; Fraser, P.D. Metabolite Profiling: A Tool for the Biochemical Characterisation of Mycobacterium sp.. Microorganisms 2019, 7, 148.

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