Special Issue "New Cationic Antimicrobial Peptides"

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 30 April 2021.

Special Issue Editors

Prof. Dr. Miguel Viñas
Website
Guest Editor
Laboratory of Molecular Microbiology & Antimicrobials Medical School, Department of Pathology and Experimental Therapeutics, University of Barcelona, Barcelona, Spain
Interests: antimicrobial agents; antimicrobial peptides; resistance; efflux pumps; bacterial membranes; synergism
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial resistance is one of the greatest challenges in public health. The rate of discovery of new antimicrobial agents has greatly slowed in recent decades. The number of deaths due to infections caused by resistant micro-organisms increases every year. The frequency of resistant, multi-resistant or pan-resistant bacterial isolates is continuously increasing. Thus, it is essential to investigate new alternatives to conventional antibiotics. Among the alternatives envisaged for this purpose antimicrobials peptides emerge as the most promising alternative.

Antimicrobial peptides (AMPs), either natural or synthetic, are viewed as molecules of extraordinary interest for their ability to kill multidrug-resistant bacteria, but also for their ability to sensitize bacteria to some agents to which they had become resistant.

We invite you to contribute to this Special Issue by submitting papers on purification, synthesis, determination of antimicrobial activity, mechanisms of action, interaction between peptides and membranes, antimicrobial peptides targets, and related topics.

Prof. Dr. Miguel Viñas
Prof. Dr. Fernando Albericio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial peptides (AMPs)
  • organic synthesis
  • natural antimicrobial peptides
  • effects of antimicrobial peptides on bacterial membranes
  • targets of AMP
  • interaction between AMPs and antibiotics
  • AMPs and efflux pumps

Published Papers (1 paper)

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Research

Open AccessArticle
Application of Natural Neutrophil Products for Stimulation of Monocyte-Derived Macrophages Obtained before and after Osteochondral or Bone Injury
Microorganisms 2021, 9(1), 124; https://doi.org/10.3390/microorganisms9010124 - 07 Jan 2021
Abstract
We evaluated the use of some neutrophil products, namely; autologous rabbit antimicrobial neutrophil extract (rANE), heterologous porcine antimicrobial neutrophil extract (pANE), neutrophil degranulation products (DGP) and neutrophil microvesicles (MVs) for stimulation of monocyte-derived macrophages (MDMs) to improve healing. Two animal models were evaluated; [...] Read more.
We evaluated the use of some neutrophil products, namely; autologous rabbit antimicrobial neutrophil extract (rANE), heterologous porcine antimicrobial neutrophil extract (pANE), neutrophil degranulation products (DGP) and neutrophil microvesicles (MVs) for stimulation of monocyte-derived macrophages (MDMs) to improve healing. Two animal models were evaluated; the rabbit model for autologous osteochondral transplantation (OT) with application of rabbit ANE, DGP or MVs for MDMs stimulation, and the ovine model of the insertion of a Ti implant with the use of porcine ANE, and ovine DGP or MVs for MDMs stimulation. Macrophage activity was assessed on the basis of free radical generation and arginase activity. We estimated that DGP acted in a pro-inflammatory way both on rabbit and ovine MDMs. On the other hand, MVs acted as anti-inflammatory stimulator on MDMs in both experiments. The response to ANE depended on origin of extract (autologous or heterologous). Macrophages from rabbits before and after OT stimulated with autologous extract generated lower amount of NO and superoxide, especially after transplantation. In the ovine model of Ti implant insertion, heterologous ANE evoked increased macrophage pro-inflammatory activity. Our study revealed that these neutrophil products could regulate activity of macrophages, polarizing them into pro-or anti-inflammatory phenotypes that could enhance bone and osteochondral tissue healing. Full article
(This article belongs to the Special Issue New Cationic Antimicrobial Peptides)
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