Latest Advances on Synthesis, Purification, and Characterization of Peptides and Their Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 2950

Special Issue Editors

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Guest Editor
1. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
2. Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 12321, Egypt
Interests: coupling reagents; all aspects of the synthesis of peptides and their medicinal application

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Guest Editor
1. School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa
2. Department of Organic Chemistry, University of Barcelona, Barcelona, Spain
Interests: antimicrobial peptides; solid-phase chemistry; combinatorial chemistry; drug delivery systems; peptide drug conjugates; orthogonal chemistry; drug discovery; biomaterials
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Special Issue Information

Dear Colleagues,

Peptides have a broad range of applications: from biochemical tools to diagnostic kits; from nanotechnology to new materials; from vaccines to drugs. These have become possible thanks to three major developments: (i) new chemical synthetic methods; (ii) purification; and (iii) characterization. The combination of the three allows the synthesis of almost any peptide from an mg to a multiKg scale.

In this Special Issue of Applied Sciences, the latest advances in all the above fields will be described and analyzed. In addition to solid-phase peptide synthesis (SPPS), which is the strategy of choice for the synthesis of the largest part of peptides, emerging technologies such as liquid-phase peptide synthesis (LPPS), flow-continuous peptide synthesis, and multiple peptide synthesis will be covered. Coupling reagents, protecting groups, resins for SPPS, tags for LPPS, reversed phase and supercritical fluid chromatography and mass spectrometry with the aim of greening all processes will be the common threads of this issue.

Prof. Dr. Ayman El-Faham
Prof. Dr. Fernando Albericio
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • solid-phase peptide synthesis
  • liquid-phase peptide synthesis
  • activation and coupling
  • protecting groups
  • green synthesis
  • chromatography
  • mass spectrometry
  • biological applications

Published Papers (1 paper)

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4 pages, 175 KiB  
Latest Advances on Synthesis, Purification, and Characterization of Peptides and Their Applications
by Ayman El-Faham, Beatriz G. de la Torre and Fernando Albericio
Appl. Sci. 2021, 11(12), 5593; - 17 Jun 2021
Cited by 3 | Viewed by 2040
Peptides have a broad number of applications: from biochemical tools to diagnostic kits; from nanotechnology to new materials; and from vaccines to drugs [...] Full article
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