Special Issue "Strategies and Weapons to Fight Antimicrobial Resistance"
Deadline for manuscript submissions: 30 April 2019
Prof. Dr. Miguel Viñas
Dr. Josep M. Sierra
The MDPI executive editors have invited us to edit a Special Issue of Microorganisms devoted to summarizing data and perspectives on the newest strategies and weapons to be used in fighting the worldwide problem posed by antimicrobial resistance. Pharmaceutical techniques, combinations of antibiotics, the use of antimicrobial peptides both natural or synthetic, the inhibition of efflux pumps, new combinations of old antibiotics, the use of nanotechniques, or the use of light and photosensitizers appear to be theoretically useful tools for the near future. Moreover, a deeper knowledge of the mechanisms of both antibiotic action and resistance should constitute the basis for further developments. Theoretical chemistry and modeling may greatly contribute to this objective. The main purpose of this Special Issue is to present the state-of-the-art on this topic.
Prof. Miguel Viñas
Dr. Josep M. Sierra
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Antimicrobial peptides
- Efflux pump inhibitors
- Photodynamic effect
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Association of posaconazole and amphotericin B in the treatment of biofilms of Candida glabrata
Authors: Célia Fortuna Rodrigues, et al
Abstract: Candidaemia is increasing, especially among immunosuppressed individuals. Of all species, Candida glabrata is one of the most drug resistant, especially to the azole class, being, thus, important to search for therapeutic alternatives. The minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and minimum biofilm eradicatory concentration (MBEC) were determined for posaconazole (Pcz) and amphotericin B (AmB). The drug combinations of both drugs were evaluated on pre-formed biofilms of C. glabrata ATCC2001, through XTT assay, colony forming units (CFU), crystal violet and the fractional inhibitory concentration index (FICI) was also determined. C. glabrata showed a higher susceptibility and biofilm reduction when using AmB alone, but both drugs revealed a good capacity in the biomass elimination. In the majority of the tested combinations, the interactions were defined as indifferent (FICI≤4). The association of the drugs, does not seem to bring a clear advantage in the treatment of biofilms of C. glabrata.