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Special Issue "Microfluidic Applications in Synthetic Biology and Development of the Artificial Cell"
Deadline for manuscript submissions: 30 September 2019.
Dr. Cherng-Wen Darren Tan Website E-Mail
Institute of Synthetic Bioarchitectures, University of Natural Resources and Life Sciences (BOKU), Austria
Interests: model biological membranes; in vitro membrane-assisted protein synthesis; artificial cell structures; protein-mediated membrane fusion; novel HIV/AIDS treatment
The quest for understanding and mimicking complex cellular structure and function has given rise to the field of synthetic biology - often boasted as the technology of the 21st century - which has tremendous potential to constructively disrupt biopharmaceutical, agricultural and biofuel industries. A major aim of synthetic biology is also to produce autopoietic systems - artificial cells - capable of persisting under various conditions and designed to perform myriad, often novel, functions of our choosing. Closely following the heels of synthetic biology is the recent maturation of microfluidic technologies. These powerful techniques give us unprecedented access to phenomena at dimensions of scale matching those of cells and cellular components. This has provided us with fine control and awareness over the microenvironment, including input stimuli and the output response, of cells. Microfluidics also allows us to track and probe single cells over extended periods of time, making it a powerful alternative to conventional cell studies. As such, microfluidic systems are admirably suited for studies involving cell-like material. Most importantly, it makes possible the controlled production of vesicle-like microdroplets, each a compartment embodying a specific cellular chemical machine, so important for multiparameter analyses. From this capability might come not only the production, but also the analysis, of organelle-like or even cell-like constructs. For these reasons, and many others, synthetic biologists have begun incorporating microfluidic applications in their work. In this special issue, Microfluidic Applications in Synthetic Biology and Development of the Artificial Cell, we invite researchers to present their novel findings and research advancements. Microfluidics-based work, involving both top-down approaches using cell-derivatives or bottom-up approaches for constructing modular cellular components, will be considered in this issue. We also invite the community to submit relevant and impactful work such as nucleic acid assembly, high throughput screening methodologies using microdroplets, cell-on-a-chip approaches, as well as advances in microfabrication that would impact synthetic biology. This special issue will comprise original research work, short communications, critical and tutorial reviews, and insights or perspectives related to this topic.
Dr. Chaitanya Kantak
Dr. Cherng-Wen Darren Tan
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- artificial organelles
- multiparameter analysis