Effect of Tryptophan Metabolism on Neuropsychiatry and Cancer Immunotherapy

Dear Colleagues,

The metabolism of amino acids, especially tryptophan, produces various metabolites that affect human health. Serotonin and melatonin are involved in regulating mood and sleep, and many intermediates of the kynurenine pathway have neuroprotective or neurodegenerative effects. The kynurenine pathway provides the precursor for NAD biosynthesis, is a key regulator of the immune system, and is hijacked by many cancers to evade the innate immune response. The aim of this Special Issue is to highlight how the metabolic pathways for tryptophan affect disease states related to neuropsychiatry and immunotherapy for treating cancer. Specific areas include, but are not limited to, the identification or detection of biomarkers, mechanistic studies of metabolic enzymes, the effects of metabolites or enzyme expression on cells, tissues, or organisms, and bioinformatics.

Dr. Ian Davis
Guest Editor

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