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Open AccessArticle

High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men—A Metabolomic Approach

1
Institute of Sports and Sports Science, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany
2
Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, 76131 Karlsruhe, Germany
3
Department of Sport and Exercise Science, University of Stuttgart, 70174 Stuttgart, Germany
*
Author to whom correspondence should be addressed.
Metabolites 2019, 9(7), 137; https://doi.org/10.3390/metabo9070137
Received: 28 May 2019 / Revised: 28 June 2019 / Accepted: 7 July 2019 / Published: 10 July 2019
(This article belongs to the Special Issue Exercise Metabonomics)
High-intensity interval training (HIIT) is known to improve performance and skeletal muscle energy metabolism. However, whether the body’s adaptation to an exhausting short-term HIIT is reflected in the resting human metabolome has not been examined so far. Therefore, a randomized controlled intervention study was performed to investigate the effect of a ten-day HIIT on the resting urinary metabolome of young active men. Fasting spot urine was collected before (−1 day) and after (+1 day; +4 days) the training intervention and 65 urinary metabolites were identified by liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy. Metabolite concentrations were normalized to urinary creatinine and subjected to univariate statistical analysis. One day after HIIT, no overall change in resting urinary metabolome, except a significant difference with decreasing means in urinary hypoxanthine concentration, was documented in the experimental group. As hypoxanthine is related to purine degradation, lower resting urinary hypoxanthine levels may indicate a training-induced adaptation in purine nucleotide metabolism. View Full-Text
Keywords: metabolomics; urinary metabolome; hypoxanthine; high-intensity interval training; NMR spectroscopy; LC-MS metabolomics; urinary metabolome; hypoxanthine; high-intensity interval training; NMR spectroscopy; LC-MS
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Kistner, S.; Rist, M.J.; Krüger, R.; Döring, M.; Schlechtweg, S.; Bub, A. High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men—A Metabolomic Approach. Metabolites 2019, 9, 137.

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