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Metabolites
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Exercise Metabonomics Volume 2
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Exercise Metabonomics Volume 2

A special issue of Metabolites (ISSN 2218-1989).

Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 11473

Special Issue Editor

Dr. Vassilis Mougios

E-Mail Website
Guest Editor
Laboratory of Evaluation of Human Biological Performance, School of Physical Education and Sport Science, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
Interests: exercise biochemistry and physiology; exercise metabolomics; sport nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolomics has become an integral part of systems biology in recent decades. By enabling a holistic view of metabolism, it has been used repeatedly over the past fifteen years in the study of the effects of exercise, both acute and chronic, on human and animal metabolism. Thus, the field of exercise metabonomics has emerged, which can be defined as the large-scale, comprehensive study of the effects of exercise on the metabolome. More than 200 original studies have been published in this area, half of them in the last three years alone. After completion of a successful Special Issue in 2020 (https://www.mdpi.com/journal/metabolites/special_issues/exercise_metabonomics), we are hereby launching volume 2. As with the original one, the aim of the present Special Issue is to advance the field of exercise metabonomics by providing a forum for the presentation of research findings with a metabolomics approach, related to the modulation of metabolism by different exercise parameters (such as type, intensity, duration, and whether it is acute or chronic), characteristics of the exercising organism (such as species, sex, age, nutritional state, training state, and the genome), and environmental factors (such as ambient temperature and hypoxia). We welcome your submissions.

Prof. Vassilis Mougios
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exercise
  • metabolomics/metabonomics
  • physical activity

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Published Papers (2 papers)

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Research

20 pages, 2157 KiB  
Article
“Fuel for the Damage Induced”: Untargeted Metabolomics in Elite Rugby Union Match Play
by James F. Hudson, Marie M. Phelan, Daniel J. Owens, James P. Morton, Graeme L. Close and Claire E. Stewart
Metabolites 2021, 11(8), 544; https://doi.org/10.3390/metabo11080544 - 17 Aug 2021
Cited by 10 | Viewed by 4813
Abstract
The metabolic perturbations caused by competitive rugby are not well characterized. Our aim is to utilize untargeted metabolomics to develop appropriate interventions, based on the metabolic fluctuations that occur in response to this collision-based team sport. Seven members of an English Premiership rugby [...] Read more.
The metabolic perturbations caused by competitive rugby are not well characterized. Our aim is to utilize untargeted metabolomics to develop appropriate interventions, based on the metabolic fluctuations that occur in response to this collision-based team sport. Seven members of an English Premiership rugby squad consented to provide blood, urine, and saliva samples daily, over a competitive week including gameday (GD), with physical demands and dietary intake also recorded. Sample collection, processing and statistical analysis were performed in accordance with best practice set out by the metabolomics standards initiative employing 700 MHz NMR spectroscopy. Univariate and multivariate statistical analysis were employed to reveal the acute energy needs of this high intensity sport are met via glycolysis, the TCA cycle and gluconeogenesis. The recovery period after cessation of match play and prior to training recommencing sees a re-entry to gluconeogenesis, coupled with markers of oxidative stress, structural protein degradation, and reduced fatty acid metabolism. This novel insight leads us to propose that effective recovery from muscle damaging collisions is dependent upon the availability of glucose. An adjustment in the periodisation of carbohydrate to increase GD+1 provision may prevent the oxidation of amino acids which may also be crucial to allay markers of structural tissue degradation. Should we expand the ‘Fuel for the work required’ paradigm in collision-based team sports to include ‘Fuel for the damage induced’? Full article
(This article belongs to the Special Issue Exercise Metabonomics Volume 2)
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15 pages, 1925 KiB  
Article
Four Weeks of Probiotic Supplementation Alters the Metabolic Perturbations Induced by Marathon Running: Insight from Metabolomics
by Jamie N. Pugh, Marie M. Phelan, Eva Caamaño-Gutiérrez, S. Andy Sparks, James P. Morton, Graeme L. Close and Daniel J. Owens
Metabolites 2021, 11(8), 535; https://doi.org/10.3390/metabo11080535 - 11 Aug 2021
Cited by 8 | Viewed by 5793
Abstract
Few data are available that describe how probiotics influence systemic metabolism during endurance exercise. Metabolomic profiling of endurance athletes will elucidate mechanisms by which probiotics may confer benefits to the athlete. In this study, twenty-four runners (20 male, 4 female) were block randomised [...] Read more.
Few data are available that describe how probiotics influence systemic metabolism during endurance exercise. Metabolomic profiling of endurance athletes will elucidate mechanisms by which probiotics may confer benefits to the athlete. In this study, twenty-four runners (20 male, 4 female) were block randomised into two groups using a double-blind matched-pairs design according to their most recent Marathon performance. Runners were assigned to 28-days of supplementation with a multi-strain probiotic (PRO) or a placebo (PLB). Following 28-days of supplementation, runners performed a competitive track Marathon race. Venous blood samples and muscle biopsies (vastus lateralis) were collected on the morning of the race and immediately post-race. Samples were subsequently analysed by untargeted 1H-NMR metabolomics. Principal component analysis (PCA) identified a greater difference in the post-Marathon serum metabolome in the PLB group vs. PRO. Univariate tests identified 17 non-overlapped metabolites in PLB, whereas only seven were identified in PRO. By building a PLS-DA model of two components, we revealed combinations of metabolites able to discriminate between PLB and PRO post-Marathon. PCA of muscle biopsies demonstrated no discernible difference post-Marathon between treatment groups. In conclusion, 28-days of probiotic supplementation alters the metabolic perturbations induced by a Marathon. Such findings may be related to maintaining the integrity of the gut during endurance exercise. Full article
(This article belongs to the Special Issue Exercise Metabonomics Volume 2)
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