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Metabolites
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Metabolic Pathways of Nutrition Intake in Obese Children
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Metabolic Pathways of Nutrition Intake in Obese Children

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (7 April 2025) | Viewed by 3074

Special Issue Editors

Dr. Edyta Łuszczki

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Guest Editor
Institute of Health Sciences, Medical College of Rzeszów University, Rzeszów, Poland
Interests: children and adolescents; nutrition; obesity; physical activity; public health
Special Issues, Collections and Topics in MDPI journals
Dr. Katarzyna Dereń

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Guest Editor
Institute of Health Sciences, Medical College of Rzeszów University, Rzeszów, Poland
Interests: nutrition; epidemiology; obesity; diet; children
Special Issues, Collections and Topics in MDPI journals
Dr. Anna Bartosiewicz

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Guest Editor
Institute of Health Sciences, Medical College of Rzeszów University, Rzeszów, Poland
Interests: health promotion; physical activity; public health; nutrition; obesity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Childhood obesity has become a worldwide epidemic in both the developed and developing world. Increased body mass index (BMI) and childhood obesity have significant long-term consequences, including an increased risk of developing chronic diseases such as type 2 diabetes (T2D) and cardiovascular disease (CVD), as well as impaired mental health, social, and economic outcomes. Elucidating the mechanisms of development of childhood obesity at the molecular level may contribute to identifying potential targeted intervention approaches to prevent childhood obesity and clarify the links between obesity and metabolic disease. Many dietary patterns are implicated in the pathway to childhood obesity, either as protective ones, such as the Mediterranean diet pattern, or as harmful ones, such as the Western-type diet pattern. Finally, nutrient intake in the context of childhood obesity could be impaired due to unhealthy eating patterns, and specific nutrients could be lacking in the diets of overweight or obese children. This could result in nutrient deficiencies that could have a harmful effect on their health.

Nutrition is a key part of the imbalance in energy intake and energy expenditure that, through complicated and poorly understood pathways, results in obesity. Metabolic pathways are highly coordinated and regulated to meet the body’s energy requirements throughout the day and night, and they provide molecules required for tissue growth and maintenance. When nutrients are plentiful, anabolic processes build up stores (glycogen and fats) which can be used catabolically to generate energy when nutrients are scarce. High-energy molecules generated by the oxidation of nutrients (carbohydrates, proteins, and fats) are used as an energy source for processes such as active transport and muscle contraction. The aim of this Special Issue of Metabolites is to highlight new insights into the complex role that nutrition plays in the etiology of childhood obesity.

Dr. Edyta Łuszczki
Dr. Katarzyna Dereń
Dr. Anna Bartosiewicz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • children and adolescents
  • dietary habits
  • Mediterranean diet
  • metabolic pathways
  • metabolic diseases
  • nutrition
  • obesity
  • Western-type diet

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Published Papers (2 papers)

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Research

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18 pages, 388 KiB  
Article
Childhood Obesity and Overweight Are Associated with Higher Risk of Perceived Stress and Poor Sleep Quality: A Cross-Sectional Study in Children Aged 6–9 Years
by Maria Mentzelou, Aikaterini Louka, Theophanis Vorvolakos, Maria G. Kapetanou, Aspasia Seradri, George Antasouras, Christos Kontogiorgis, Georgia-Eirini Deligiannidou, Maria Chrysafi and Constantinos Giaginis
Metabolites 2025, 15(6), 345; https://doi.org/10.3390/metabo15060345 - 22 May 2025
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Abstract
Background/Objectives: The number of children with overweight and obesity is gradually increasing worldwide. This is an emergent public health problem as overweight and obesity persist through the next stages of human life, being associated with high risk of morbidity and mortality. In this [...] Read more.
Background/Objectives: The number of children with overweight and obesity is gradually increasing worldwide. This is an emergent public health problem as overweight and obesity persist through the next stages of human life, being associated with high risk of morbidity and mortality. In this respect, the purpose of the current cross-sectional survey is to explore whether the overweight/obesity of children aged 6–9 years may be related to the risk of developing perceived stress and poor sleep quality symptoms. Methods: This study recruited 4350 primary school children from diverse Greek rural and urban regions. The mothers of the enrolled children completed relevant questionnaires on children and maternal sociodemographics, anthropometric parameters, perinatal outcomes, breastfeeding practices, and lifestyle factors. The enrolled mothers also completed the Perceived Stress Scale (PSS) and the Pittsburgh Sleep Quality Index (PSQI) to evaluate the perceived stress and sleep quality of their matched children, respectively. Results: Our analysis reveals independently significant associations between diverse factors and children’s overweight/obesity such as child’s gender, family economic status, maternal gestational weight gain, childbirth weight, kind of delivery, exclusive breastfeeding, and children physical activity. Childhood overweight and obesity were independently associated with a more than three-fold higher risk of perceived stress and a more than two-fold higher likelihood of poor sleep quality after adjustment for multiple confounding factors. Conclusions: Obesity and overweight are related to enhanced risk of perceived stress and poor sleep quality in children aged 6–9 years. Public policies and dietary counseling interventions should be applied to inform new mothers about the harmful effects of childhood overweight/obesity and to direct them to adopt healthy dietary practices for their children. Full article
(This article belongs to the Special Issue Metabolic Pathways of Nutrition Intake in Obese Children)
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Review

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20 pages, 1159 KiB  
Review
The Effect of Maternal Diet and Lifestyle on the Risk of Childhood Obesity
by Edyta Łuszczki, Justyna Wyszyńska, Agnieszka Dymek, Dorota Drożdż, Laura González-Ramos, Isa Hartgring, Nuria García-Carbonell, Artur Mazur, Serap Erdine, Justė Parnarauskienė and Julio Alvarez-Pitti
Metabolites 2024, 14(12), 655; https://doi.org/10.3390/metabo14120655 - 25 Nov 2024
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Abstract
Background/Objectives: Childhood obesity is a global health problem that affects at least 41 million children under the age of five. Increased BMI in children is associated with serious long-term health consequences, such as type 2 diabetes, cardiovascular disease, and psychological problems, including [...] Read more.
Background/Objectives: Childhood obesity is a global health problem that affects at least 41 million children under the age of five. Increased BMI in children is associated with serious long-term health consequences, such as type 2 diabetes, cardiovascular disease, and psychological problems, including depression and low self-esteem. Although the etiology of obesity is complex, research suggests that the diet and lifestyle of pregnant women play a key role in shaping metabolic and epigenetic changes that can increase the risk of obesity in their children. Excessive gestational weight gain, unhealthy dietary patterns (including the Western diet), and pregnancy complications (such as gestational diabetes) are some of the modifiable factors that contribute to childhood obesity. The purpose of this narrative review is to summarize the most important and recent information on the impact of the diet and lifestyle of pregnant women on the risk of childhood obesity. Methods: This article is a narrative review that aims to summarize the available literature on the impact of pregnant women’s diet and lifestyle on the risk of obesity in their offspring, with a focus on metabolic and epigenetic mechanisms. Results/Conclusions: Current evidence suggests that a pregnant woman’s lifestyle and diet can significantly contribute to lowering the risk of obesity in their offspring. However, further high-quality research is needed to understand better the metabolic and epigenetic relationships concerning maternal factors that predispose offspring to obesity. Full article
(This article belongs to the Special Issue Metabolic Pathways of Nutrition Intake in Obese Children)
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