Metabolomics in Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Pharmacology and Drug Metabolism".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 904
Special Issue Editor
Special Issue Information
Dear Colleagues,
Issues related to drug safety remain a major bottleneck in drug discovery and development. Recent technological advancements in metabolomics have enabled researchers to measure a large number of compounds in large sets of samples, as well as in single cells. These new advancements have helped us to gain insights into the mechanisms of drug toxicity, translatability to humans, prediction of safety events, mitigation of side effects, and development of safety biomarkers. Metabolomics applied to drug metabolism, drug–endobiotic interactions, and drug–drug (food) interactions offers an ideal opportunity to study the toxicological effects of drugs.
This Special Issue is devoted to metabolomics in drug metabolism, drug–drug (food) interactions, and drug toxicity. The topics that will be covered include studies on the metabolomic analyses of the fate of drugs and host responses to drugs (including new modalities such as peptides, antibody–drug conjugates, protein therapeutics, and oligonucleotide therapeutics), as well as endogenous probes for drug–drug (food) interactions. Additional topics include metabolomic analyses of studying the mechanism, prediction, and safety biomarkers of drug toxicity. Other topics with a similar focus will also be considered.
Dr. Pengcheng Wang
Guest Editor
Manuscript Submission Information
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Keywords
- metabolomics
- drug/xenobiotic metabolism
- drug–drug interactions
- drug toxicity
- ADME
- new modalities peptides
- antibody-drug conjugates
- protein therapeutics
- oligonucleotide therapeutics
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