Advances in Translational Oncology and Oncometabolism
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 129
Special Issue Editors
Interests: bioactive lipids; obesity; GI cancer; adipose tissue and therapeutic response; adiposity and molecular targeted therapy
Interests: extracellular vesicles; lung cancer; mesothelioma; GI cancers; tumour microenvironment; tumour metabolism; drug-induced neuropathy
Special Issue Information
Dear Colleagues
Recent advances in oncometabolism have deepened our understanding of the metabolic alterations in cancer cells, highlighting the potential for metabolic-based diagnostics and therapies in oncology. Tumour metabolism has been identified a newer hallmark of cancer that supports their rapid growth and survival. Many oncogenes and tumour suppressor genes regulate metabolism as part of their mechanism in driving tumorigenesis. Recent technological advancements in onco-metabolism include high-throughput techniques to enable the comprehensive analysis of metabolic profiles and identify metabolic alterations in cancer cells. The use of stable isotype tracing with labelled substrates enables the tracking of metabolic fluxes in vivo, providing insights into metabolic pathways active in tumours.
Cancer cells often undergo significant metabolic changes to meet the bioenergetic and biosynthetic demands of rapid proliferation. This includes alterations in glucose metabolism, amino acid metabolism, and lipid metabolism. Cancer stem cells are often linked to altered tumour metabolism and failure to respond to various cancer treatments. Identifying specific onco-metabolites can lead to the development of diagnostic biomarkers for early cancer detection. Furthermore, understanding how the tumour microenvironment influences metabolism in the context of molecular mutations could pave the way for more effective, personalized therapies across various types of cancer.
This Special Issue of Metabolites aims to examine current advances in the field of tumour metabolism, with a focus on translational oncology as it relates to molecular mutations, adipocytes in the tumour microenvironment and response to therapy.
Dr. Graham Pidgeon
Dr. Zivile Useckaite
Guest Editors
Manuscript Submission Information
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Keywords
- oncometabolism
- obesity
- clinical research
- clinical trials
- oncogenes
- translational oncology
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