Advancing Metabolic/Microbial Biomarker Applications in Disease Prevention, Diagnosis and Public Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 432

Special Issue Editors


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Guest Editor
Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310052, China
Interests: environmental toxicology; gut microbiota; metabolomics
Special Issues, Collections and Topics in MDPI journals
School of Marine Sciences, Nanjing University of Information Science and Technology, Nanjing 210044, China
Interests: metabolomics; lipidomics; stable isotope tracing; gut microbiota; multiomics; environmental toxicology; alcohol-related liver disease
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Special Issue Information

Dear Colleagues,

With the rapid advancement of biomedical research, the study of biomarkers has become a crucial topic in disease prevention, diagnosis, and public health. Biomarkers can act as distinctive metabolic signatures for specific diseases, thus revealing the biological features and mechanisms of diseases.

Various biological indicators have been incorporated into biomarker research. These indicators are no longer limited to traditional metabolites and metabolic biomarkers but also include the gut microbiota and their metabolic products. Moreover, the analysis of various biological matrices, such as blood, feces, urine, and saliva, has provided new opportunities for the multidimensional detection of biomarkers. We welcome the submission of research and review articles that investigate the application of biomarkers in disease prevention, diagnosis, and public health initiatives. Biomarker categories encompass metabolic indicators, metabolites, the gut microbiota, and other related biological signatures. In addition, we welcome the submission of both traditional and novel biomarker research. This Special Issue seeks to advance the application of biomarkers to enhance early disease detection, enable precision medicine, and inform public health interventions, ultimately promoting innovation in biomedical research and public health.

Dr. Pengcheng Tu
Dr. Bei Gao
Guest Editors

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Keywords

  • biomarkers
  • disease processes
  • gut microbiome
  • multi-omics
  • metabolic indicators
  • clinical applications

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Published Papers (1 paper)

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Review

17 pages, 663 KB  
Review
Gut Microbiota in Acute Myeloid Leukemia: From Biomarkers to Interventions
by Meifen Ji, Meixia Ji, Yebo Zhong and Lewen Shao
Metabolites 2025, 15(9), 568; https://doi.org/10.3390/metabo15090568 - 25 Aug 2025
Viewed by 269
Abstract
Acute myeloid leukemia (AML), the most common acute leukemia among adults, poses significant therapeutic challenges due to diagnostic limitations and the frequent development of treatment resistance. While genomics-based approaches have advanced, DNA aberrations do not always reflect the expression levels of genes and [...] Read more.
Acute myeloid leukemia (AML), the most common acute leukemia among adults, poses significant therapeutic challenges due to diagnostic limitations and the frequent development of treatment resistance. While genomics-based approaches have advanced, DNA aberrations do not always reflect the expression levels of genes and proteins, which are more tightly connected to disease phenotypes. Recently, the role of the gut microbiota in AML has gained increasing attention. AML patients often exhibit gut microbiota dysbiosis, which is linked to disease progression and heightened infection risk. Mounting evidence indicates that gut microbiota metabolism influences hematopoiesis and immune function via the “gut-bone marrow axis,” with microbiota composition and diversity significantly affecting treatment outcomes and prognosis. High-throughput sequencing and metabolomics have identified correlations between gut microbiota composition and its metabolic products with AML clinical characteristics, paving the way for new biomarkers in diagnosis and prognosis. Additionally, treatments such as fecal microbiota transplantation (FMT) show promise in enhancing chemotherapy efficacy and improving patient outcomes. This review highlights recent advances in understanding the role of the gut microbiota in AML and explores new perspectives for its diagnosis and treatment. Full article
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