Advances in Phytomedicine Intervention on Metabolic Disorders

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1576

Special Issue Editor


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Guest Editor
Xiangya School of Public Health, Central South University, Changsha 410078, China
Interests: prevention and treatment of nutritional-related metabolic diseases; physiological effects and mechanisms of phytochemicals
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Special Issue Information

Dear Colleagues,

We invite you to submit original research or review articles to this Special Issue titled “Advances in Phytomedicine Intervention on Metabolic Disorders”.

Metabolic disorders, including obesity, diabetes, and gout, pose a significant global health burden. Poor nutritional status is highly correlated with the occurrence and progression of metabolic diseases. Recent studies suggest that metabolic disorders can be managed through dietary interventions that utilize plant-based nutrients or phytochemicals. However, identifying edible plants with therapeutic potential for metabolic disorders remains an area of active research. We emphasize the importance of screening such plants, focusing on their bioactive compounds, targets, pathways, and mechanisms of action. Therefore, this Special Issue, titled “Advances in Phytomedicine Intervention on Metabolic Disorders,” will highlight studies on the mechanisms of edible plants in treating metabolic disorders. We especially welcome research on the physiological effects, pharmacological actions, and detailed mechanisms of edible plants during intervention and treatment processes. This includes, but is not limited to, the identification of newly discovered edible plants with therapeutic potential for metabolic disorders, the validation of plant-derived active components with anti-inflammatory and anti-aging properties, pharmacological studies of edible plants ameliorating metabolic disorders through multi-omics and systems biology approaches, and studies involving signaling pathways and gene or protein regulation during therapeutic processes. We invite original research articles and reviews related to this theme.

Prof. Dr. Hong Qin
Guest Editor

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Keywords

  • metabolic disorders
  • glucose and lipid metabolism
  • insulin resistance
  • non-communicable diseases
  • energy imbalance
  • nutrients
  • phytochemicals
  • plant ac-tive components
  • inflammation
  • signaling pathway

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Published Papers (1 paper)

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Research

15 pages, 2093 KiB  
Article
Exploring the In Vitro Effects of Zingerone on Differentiation and Signalling Pathways in Bone Cell Lines
by Brunhildé De Vos, Abe E. Kasonga, Anna M. Joubert and Trevor T. Nyakudya
Metabolites 2024, 14(12), 693; https://doi.org/10.3390/metabo14120693 - 9 Dec 2024
Viewed by 1246
Abstract
Objective: Ensuring adequate bone health is crucial for preventing conditions such as osteoporosis and fractures. Zingerone, a phytonutrient isolated from cooked ginger, has gained attention for its potential benefits in bone health. This study evaluated the osteoprotective potential of zingerone and its effects [...] Read more.
Objective: Ensuring adequate bone health is crucial for preventing conditions such as osteoporosis and fractures. Zingerone, a phytonutrient isolated from cooked ginger, has gained attention for its potential benefits in bone health. This study evaluated the osteoprotective potential of zingerone and its effects on differentiation and signalling pathways in vitro using SAOS-2 osteosarcoma and RAW264.7 macrophage cell lines, aiming to elucidate its mechanism of action in bone remodelling. Methods: SAOS-2 osteosarcoma and RAW264.7 macrophage cells were treated with zingerone at concentrations of 200 µM. Osteoblast differentiation was assessed by alkaline phosphatase (ALP) activity, bone mineralisation via Alizarin Red S stain, and gene expression markers (ALP, runt-related transcription factor 2 (Runx2), and osteocalcin) via quantitative polymerase chain reaction (q-PCR). Osteoclast differentiation was evaluated by tartrate-resistant acid phosphatase (TRAP) staining, TRAP activity, and mitogen-activated protein kinase (MAPK) pathways. Results: Treatment with zingerone was non-toxic at 200 µM. Zingerone (200 µM) significantly stimulated the gene expression of ALP and Runx2 in SAOS-2 cells (p < 0.05) without statistically significantly enhancing SAOS-2 mineralisation via calcium deposits. Moreover, zingerone significantly inhibited osteoclast differentiation in RAW264.7 cells as evidenced by reduced TRAP staining and activity (p < 0.05). Conclusions: Zingerone shows promise in reducing osteoclast activity and supporting early osteoblast differentiation, suggesting its potential as a dietary supplement for bone health. Further in vivo and clinical studies are needed to confirm its role in managing osteoporosis. Full article
(This article belongs to the Special Issue Advances in Phytomedicine Intervention on Metabolic Disorders)
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