Primary Hyperparathyroidism: Mechanisms and Treatment
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 8353
Special Issue Editors
Interests: bone; parathyroid; primary hyperparathyroidsm; calcium; phosporus
Interests: advancing the understanding of bone and muscle interplay to develop innovative biomarkers and therapies that improve musculoskeletal health and patient outcomes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders, characterized by hypercalcemia and elevated or unsuppressed levels of parathyroid hormone (PTH) due to dysfunction in one or more parathyroid glands. Historically, PHPT has often been associated with severe skeletal and renal complications, but milder forms of the disease, including asymptomatic and normocalcemic PHPT, have become more prevalent in recent years.
In patients with classic symptomatic PHPT, diagnosis is straightforward, and the primary treatment is surgical parathyroidectomy, which restores calcium and PTH levels and often improves bone mineral density (BMD) while reducing the risk of nephrolithiasis. However, in milder forms of the disease, such as normocalcemic PHPT, diagnosis is more challenging and treatment decisions are more complex. Recent studies suggest a trend toward earlier intervention, even in cases with less severe biochemical abnormalities, given the long-term metabolic consequences of untreated disease.
Parathyroidectomy has been shown to lead to significant metabolic improvements, including increased BMD and a reduction in kidney stone formation. While medical therapies can also improve BMD or lower serum calcium, no single agent has been found to address both issues simultaneously.
The metabolic impact of PHPT extends beyond calcium and phosphate homeostasis, affecting bone remodeling, renal function, and potentially other metabolic pathways. Understanding the biochemical markers associated with disease progression and treatment response is critical in optimizing management. Furthermore, the localization of hyperfunctioning parathyroid tissue, particularly in cases of multiglandular disease or ectopic adenomas, presents additional challenges that can complicate both diagnosis and treatment.
This Special Issue will explore the metabolic mechanisms underlying PHPT, from calcium and bone metabolism to the clinical effects of surgical and medical interventions. By examining the metabolic pathways involved in PHPT and the metabolic outcomes of treatment strategies, we aim to provide insights into more personalized and effective management of this common endocrine disorder.
Dr. Elena Castellano
Dr. Federica Saponaro
Guest Editors
Manuscript Submission Information
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Keywords
- primary pyperparathyroidism
- mechanism
- metabolism
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