Advances in Diagnosis and Treatment of Cervical Cancer

A Special Issue of Medicina (ISSN 1648-9144) belonging to the section "Obstetrics and Gynecology".

Deadline for manuscript submissions: closed (31 March 2026) | Viewed by 1485

Editors


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Guest Editor
1. Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy
2. Unit of Obstetrics and Gynecology, “Paolo Giaccone” Hospital, 90127 Palermo, Italy
Interests: endometriosis; infertility; minimally invasive surgery; assisted reproduction technology; gynecological endocrinology; reproductive immunology; laparoscopy; hysteroscopy
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Guest Editor Assistant
Unit of Obstetrics and Gynecologic Oncology, Fondazione Istituto Giglio, Cefalu, Italy
Interests: endometrial cancer; laparoscopy; robotics; gynecologic oncology; hysterectomy; ovarian cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, the occurrence of cervical cancer has shown a downward trend, particularly in developed countries, due to significant progress in screening programs. Treatment options for cervical cancer vary based on specific prognostic factors and tumor-related characteristics, ranging from surgery in early-stage disease to radio–chemotherapy for locally advanced cases. Recent clinical trials have demonstrated the feasibility and oncological safety of less radical surgery for early-stage cervical cancer, substantially reducing surgical complications. At the same time, advancements in our understanding of invasive carcinoma have led to increasingly effective therapeutic approaches, including innovative immunotherapies showing promising results. Despite these advancements, cervical cancer remains a leading cause of cancer-related deaths in women, with a significant recurrence rate. Furthermore, the increasing number of women diagnosed with cervical cancer who have not yet fulfilled their reproductive aspirations highlights the urgent need for novel therapeutic strategies that prioritize fertility preservation. In light of these challenges, many critical questions remain unanswered.

This Special Issue aims to explore and synthesize the latest evidence on the optimal diagnosis and treatment of cervical cancer. We warmly invite authors to contribute systematic reviews, meta-analyses, narrative reviews, and original research articles to this Special Issue, driving progress in the management and treatment of cervical cancer.

Prof. Antonio Simone Laganà
Guest Editor

Dr. Giuseppe Cucinella
Guest Editor Assistant

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Keywords

  • cervical cancer
  • screening programs
  • surgical advancements
  • recurrence management
  • oncological outcomes
  • fertility sparing
  • minimally invasive surgery

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Published Papers (1 paper)

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Research

14 pages, 519 KB  
Article
Exploratory Analysis of Systemic Inflammatory Indices Across Locoregional Tumor Progression Parameters in Cervical Cancer: The CERTIFIKO Prospective Study
by Carlo Ronsini, Antonino Di Nuzzo, Maria Cristina Solazzo, Cono Scaffa, Costanza Ascione and Vito Chiantera
Medicina 2026, 62(8), 1570; https://doi.org/10.3390/medicina62081570 - 17 Aug 2026
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Abstract
Background and Objectives: Systemic inflammatory indices derived from routine blood tests have been proposed as potential biomarkers reflecting tumor behavior. This study aimed to evaluate their association with parameters of locoregional tumor progression in cervical cancer. Materials and Methods: This prospective observational study [...] Read more.
Background and Objectives: Systemic inflammatory indices derived from routine blood tests have been proposed as potential biomarkers reflecting tumor behavior. This study aimed to evaluate their association with parameters of locoregional tumor progression in cervical cancer. Materials and Methods: This prospective observational study (CERTIFIKO) included 79 patients with cervical cancer enrolled between July 2023 and December 2025. This study was registered on ClinicalTrials.gov (NCT05673252). Pre-treatment blood samples were used to calculate the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic inflammatory response (SIR), and systemic inflammatory response index (SIRI). Tumor progression parameters included stromal infiltration, parametrial involvement, lymphovascular space invasion (LVSI), fornix involvement, lymph node status, histotype, and grading. Associations were assessed using non-parametric tests and linear regression models. Results: Stromal infiltration was significantly associated with PLR (p = 0.011), MLR (p = 0.010), and NLR (p = 0.010). Parametrial involvement was associated with MLR (p = 0.004) and NLR (p = 0.012). Diffuse LVSI was associated with PLR (p = 0.002), NLR (p = 0.006), SIR (p = 0.008), and SIRI (p = 0.034). In multivariable linear regression models, diffuse LVSI remained associated with higher PLR and NLR values, whereas parametrial involvement remained associated with higher MLR, NLR, and SIRI. No significant associations were observed for fornix involvement, histotype, or lymph node status. Conclusions: Systemic inflammatory indices were associated with parameters of locoregional tumor progression in this exploratory cohort of patients with cervical cancer. These findings warrant further evaluation in larger studies before any potential clinical application. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Cervical Cancer)
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