Special Issue "Biomaterials for Regenerative Medicine and Drug Delivery"
Deadline for manuscript submissions: closed (30 September 2021).
Advances in biomaterials science have led to significant progress in biology and medicine, with biomaterials playing an important role in drug delivery, tissue engineering, and novel clinical therapies. Each class of biomaterials, including natural and synthetic polymers, bioactive ceramics and composites, has a set of properties which makes them appropriate for specific applications. However, the success of many regenerative medicine strategies relies on the potential to design suitable materials able to support and guide cells during tissue healing and remodeling processes.
Advanced tissue engineering systems often combine biomaterial matrices with bioactive agents, enhancing the modulation of a favorable environment for tissue regeneration. Such bioactive agents include, e.g., small molecules or bioactive ions, genes, cells, and growth factors, either being delivered in single mode or simultaneously delivering multiple stimuli to the targeted site. The choice of correct mode of active agent delivery strongly affects numerous factors that contribute to therapeutic efficacy, including pharmacokinetics, distribution, cellular uptake and metabolism, excretion, and clearance, as well as toxicity. Many bioactive agents are sensitive to the surrounding environment and must act intracellularly at the molecular level. Thus, to be effective, they require an appropriate carrier, which can take the form of a scaffold (e.g., hydrogels, bioceramics, electrospun fibers), particles (nano/micro), or genetically modified cells. Moreover, much of the success of such local or site-specific smart drug delivery systems is related to the proper combination of active agents, cells, biomaterials, and nanotechnologies.
Although much effort has been made in this field, there are still many challenges: the optimal local concentration of the bioactive agents, the lack of correlation of in vitro with in vivo drug release profiles, the effect of the local biomaterial/carrier response, and other factors that cannot be mimicked in the simple in vitro system.
This Special Issue invites manuscripts on any of abovementioned subjects, or others covering recent progress and new developments in the context of regenerative medicine and drug delivery approaches. Full papers, short communications, and reviews are welcome.
Assoc. Prof. Dagnija Loca
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- drug delivery
- regenerative medicine
- tissue engineering
- controlled release