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Article

Enzymatically Crosslinked In Situ Synthesized Silk/Gelatin/Calcium Phosphate Hydrogels for Drug Delivery

by 1,2, 1,2 and 1,2,*
1
Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Faculty of Materials Science and Applied Chemistry, Institute of General Chemical Engineering, Riga Technical University, Pulka 3/3, LV-1007 Riga, Latvia
2
Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, LV-1658 Riga, Latvia
*
Author to whom correspondence should be addressed.
Academic Editor: Xiaozhong Qu
Materials 2021, 14(23), 7191; https://doi.org/10.3390/ma14237191 (registering DOI)
Received: 7 October 2021 / Revised: 15 November 2021 / Accepted: 22 November 2021 / Published: 25 November 2021
(This article belongs to the Special Issue Biomaterials for Regenerative Medicine and Drug Delivery)
Our research focuses on combining the valuable properties of silk fibroin (SF) and calcium phosphate (CaP). SF is a natural protein with an easily modifiable structure; CaP is a mineral found in the human body. Most of the new age biocomposites lack interaction between organic/inorganic phase, thus SF/CaP composite could not only mimic the natural bone, but could also be used to make drug delivery systems as well, which can ensure both healing and regeneration. CaP was synthesized in situ in SF at different pH values, and then crosslinked with gelatin (G), horseradish peroxide (HRP), and hydrogen peroxide (H2O2). In addition, dexamethasone phosphate (DEX) was incorporated in the hydrogel and drug delivery kinetics was studied. Hydrogel made at pH 10.0 was found to have the highest gel fraction 110.24%, swelling degree 956.32%, and sustained drug delivery for 72 h. The highest cell viability was observed for the hydrogel, which contained brushite (pH 6)—512.43%. View Full-Text
Keywords: silk fibroin; calcium phosphates; composite materials; hydrogels; drug delivery; 3D visualization; cell viability silk fibroin; calcium phosphates; composite materials; hydrogels; drug delivery; 3D visualization; cell viability
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MDPI and ACS Style

Grava, A.; Egle, K.; Dubnika, A. Enzymatically Crosslinked In Situ Synthesized Silk/Gelatin/Calcium Phosphate Hydrogels for Drug Delivery. Materials 2021, 14, 7191. https://doi.org/10.3390/ma14237191

AMA Style

Grava A, Egle K, Dubnika A. Enzymatically Crosslinked In Situ Synthesized Silk/Gelatin/Calcium Phosphate Hydrogels for Drug Delivery. Materials. 2021; 14(23):7191. https://doi.org/10.3390/ma14237191

Chicago/Turabian Style

Grava, Andra, Karina Egle, and Arita Dubnika. 2021. "Enzymatically Crosslinked In Situ Synthesized Silk/Gelatin/Calcium Phosphate Hydrogels for Drug Delivery" Materials 14, no. 23: 7191. https://doi.org/10.3390/ma14237191

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