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New Furanocembranoids from Briareum violaceum

1,2,†, 3,4,†, 2, 5, 6,7, 8,9, 5,10,11,12, 4,* and 1,2,4,13,14,15,*
1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
2
Department of Planning and Research, National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
3
Department of Neurology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
4
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
5
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan
6
Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 83347, Taiwan
7
Super Micro Mass Research and Technology Center, Cheng Shiu University, Kaohsiung 83347, Taiwan
8
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266033, China
9
Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao 266235, China
10
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
11
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan
12
Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
13
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
14
Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
15
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2019, 17(4), 214; https://doi.org/10.3390/md17040214
Received: 17 February 2019 / Revised: 16 March 2019 / Accepted: 3 April 2019 / Published: 5 April 2019
(This article belongs to the Special Issue Terpenoids from Marine Organisms)
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Abstract

Three new furanocembranoids—briaviodiol F (1) and briaviotriols A (2) and B (3)—along with a known analogue, briaviodiol A (4), were obtained from a cultured-type octocoral Briareum violaceum. The structures of cembranoids 13 were elucidated by using spectroscopic methods. In vitro study demonstrated that compounds 2 and 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW 264.7, a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides. View Full-Text
Keywords: Briareum violaceum; briaviodiol; briaviotriol; anti-inflammatory; iNOS Briareum violaceum; briaviodiol; briaviotriol; anti-inflammatory; iNOS
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Huang, P.-C.; Lin, W.-S.; Peng, B.-R.; Chang, Y.-C.; Fang, L.-S.; Li, G.-Q.; Hwang, T.-L.; Wen, Z.-H.; Sung, P.-J. New Furanocembranoids from Briareum violaceum. Mar. Drugs 2019, 17, 214.

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