Special Issue "Paramagnetic MRI Contrast Agents Based on the Use of Lanthanides and Transition Metals Complexes: From Small Molecules to Supramolecular Systems"

A special issue of Magnetochemistry (ISSN 2312-7481).

Deadline for manuscript submissions: 31 May 2020.

Special Issue Editors

Dr. Giuseppe Ferrauto
Website
Guest Editor
Molecular Imaging Center, Department of Molecular Biotechnologies and Health Sciences, University of Torino, Torino, 10126, Italy
Interests: molecular imaging; magnetic resonance imaging; CEST agents; multiparametric tumor imaging; nanosized systems; photoacoustic imaging
Dr. Enza Di Gregorio
Website
Guest Editor
Molecular Imaging Center, Department of Molecular Biotechnologies and Health Sciences, University of Torino, Torino, 10126, Italy
Interests: molecular imaging; magnetic resonance imaging; T1 agents; FFC–NMRD; cancer imaging; Gd-deposition

Special Issue Information

Dear Colleagues,

This Special Issue deals with the use of metal complexes as paramagnetic MRI contrast probes.

Magnetic resonance imaging plays a key role in the field of in vivo diagnostic imaging because of its high spatial resolution, the possibility to visualize deep tissues, and the absence of invasiveness.

The use of metal-based contrast agents, mainly gadolinium-based contrast agents (GBCAs), allows enhancing the clinical information attainable by MRI scans; thus, macrocyclic and linear GBCAs are widely employed in clinical MRI scans.

In the last three decades, great attention has been devoted to the optimization of the chemical and physical properties of these contrast agents, with the aim of improving their contrastographic performance and reducing toxicity. 

In particular, the issue of increasing their sensitivity has been largely investigated both by properly designing the chemical structure of small Lanthanide complexes and by introducing macromolecular systems and supramolecular adducts (e.g., albumin-binding CAs or paramagnetic liposomes).

The development of innovative multimodal, targeted, and/or responsive agents has demonstrated that the field of contrast agents for MRI still has much to offer.

The main aim of this Special Issue is to investigate the magnetic properties of metal-based MRI contrast agents, by highlighting the relationship between their chemical structure and the biological behavior.

Dr. Giuseppe Ferrauto
Dr. Enza Di Gregorio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Magnetochemistry is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • CEST
  • FFC–NMRD, Gd complexes
  • Lanthanides
  • liposomes
  • magnetic resonance imaging
  • molecular imaging
  • nanosized systems
  • T1 agents

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Open AccessArticle
Design, Characterization and Molecular Modeling of New Fluorinated Paramagnetic Contrast Agents for Dual 1H/19F MRI
Magnetochemistry 2020, 6(1), 8; https://doi.org/10.3390/magnetochemistry6010008 (registering DOI) - 11 Feb 2020
Abstract
One major goal in medical imaging is the elaboration of more efficient contrast agents (CAs). Those agents need to be optimized for the detection of affected tissues such as cancers or tumors while decreasing the injected quantity of agents. The paramagnetic contrast agents [...] Read more.
One major goal in medical imaging is the elaboration of more efficient contrast agents (CAs). Those agents need to be optimized for the detection of affected tissues such as cancers or tumors while decreasing the injected quantity of agents. The paramagnetic contrast agents containing fluorine atoms can be used for both proton and fluorine magnetic resonance imaging (MRI), and they open the possibility of simultaneously mapping the anatomy using 1H MRI and accurately locating the agents using 19F MRI. One of the challenges in this domain is to synthesize molecules containing several chemically equivalent fluorine atoms with relatively short relaxation times to allow the recording of 19F MR images in good conditions. With that aim, we propose to prepare a CA containing a paramagnetic center and nine chemically equivalent fluorine atoms using a cycloaddition reaction between two building blocks. These fluorinated contrast agents are characterized by 19F NMR, showing differences in the fluorine relaxation times T1 and T2 depending on the lanthanide ion. To complement the experimental results, molecular dynamics simulations are performed to shed light on the 3D-structure of the molecules in order to estimate the distance between the lanthanide ion and the fluorine atoms. Full article
Show Figures

Figure 1

Back to TopTop