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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Liver Disease: Pathogenesis, Diagnosis, and Treatments

edited by Hsien-Hui Chung

submission deadline 31 Jan 2026 | Viewed by 33 | Submission Open

Keywords: alcoholic hepatitis; artificial intelligence; biomarkers; clinical trials; gut– liver axis; liver cancer; metabolic dysfunction-associated steatohepatitis; molecular targets; pharmacotherapeutic mechanisms; therapeutic strategies

(This special issue belongs to the Section Medical Research)

Current Updates on Equidae Breeding and Genetics

edited by

María Dolores Gómez Ortiz

and

Isabel Cervantes

submission deadline 31 Jan 2026 | Viewed by 29 | Submission Open

Keywords: complex trait; selection; animal welfare; genomic inbreeding; horse; donkey; mule

(This special issue belongs to the Section Animal Science)

Exploring the Mechanisms of the Effects of Microplastics and Nanomaterials on Biological Physiological Functions

edited by Yung-Li Wang

submission deadline 31 Jan 2026 | Viewed by 28 | Submission Open

Keywords: microplastics; nanomaterials; environmental toxicology; oxidative stress; physiological function

(This special issue belongs to the Section Physiology and Pathology)

Advances in the Rehabilitation of Stroke

edited by

Chia Huei Lin

submission deadline 31 Jan 2026 | Viewed by 13 | Submission Open

Keywords: stroke; acute stroke; chronic stroke; post-acute stroke; functional recovery; rehabilitation

(This special issue belongs to the Section Medical Research)

Brain Health for All Ages: Leave No One Behind

edited by

Tissa Wijeratne

and Dilani Wijeratne

submission deadline 31 Jan 2026 | Viewed by 6 | Submission Open

Keywords: brain health; neurology; neurological syndromes

(This special issue belongs to the Section Medical Research)

The Biological Impacts of Fetal Alcohol Exposure

edited by Kelly J. Huffman

submission deadline 31 Jan 2026 | Viewed by 5 | Submission Open

Keywords: fetal alcohol spectrum disorders; fetal alcohol syndrome; brain development; behavioral development; prenatal exposure

(This special issue belongs to the Section Reproductive and Developmental Biology)

Chemical Evolutionary Pathways to Origins of Life

edited by

Claudia Huber

and Christian Seitz

submission deadline 31 Jan 2026 | Viewed by 4 | Submission Open

Keywords: origin of life; metabolism-first; early Earth; iron– sulfur world; chemical evolution ; cellularization; surface catalysis; pioneer organism

(This special issue belongs to the Section Origin of Life)

New Insights into Pneumonia Pathophysiology—from Lung Fibrosis to Coagulation Disorders

edited by Mihai Lazar

submission deadline 31 Jan 2026 | Viewed by 3 | Submission Open

Keywords: pneumonia pathophysiology; lung fibrosis; coagulation disorders; thromboinflammation; immune dysregulation; diagnostic biomarkers; translational medicine

(This special issue belongs to the Section Physiology and Pathology)

Pain Epidemiology

edited by

Gergely Fehér

submission deadline 14 Feb 2026 | Viewed by 6 | Submission Open

Keywords: pain epidemiology; chronic pain; neuropathic pain; nociplastic pain; headache; migraine; orofacial pain; low back pain

(This special issue belongs to the Section Epidemiology)

Current Challenges in Human Space Flight

edited by

Larry D. Sanford

and

Richard A. Britten

submission deadline 20 Feb 2026 | 4 articles | Viewed by 10955 | Submission Open

Keywords: cognition; microgravity; sleep; stress; Martian and lunar dust; neural stem cells and progenitors

(This special issue belongs to the Section Astrobiology)

Biomechanics of Aging

edited by

Márcio Fagundes Goethel

and

Filipa Sousa

submission deadline 26 Feb 2026 | Viewed by 46 | Submission Open

Keywords: aging; biomechanics; musculoskeletal; gait; balance; falls; exercise; assistive devices

(This special issue belongs to the Section Physiology and Pathology)

The Link Between Food Safety and Microbiology

edited by

Babak Pakbin

submission deadline 26 Feb 2026 | Viewed by 43 | Submission Open

Keywords: food safety; food microbiology; beneficial microbes; food preservation; food safety enhancement

Oral Health: Microbial Dynamics and Antibiotic Stewardship

edited by Kristina Peroš

submission deadline 26 Feb 2026 | Viewed by 36 | Submission Open

Keywords: oral health; oral microbiota; microbial dynamics; antibiotic stewardship

(This special issue belongs to the Section Microbiology)

Skin Aging and Dermatosis

edited by Edwin Lephart and Zoe D. Draelos

submission deadline 26 Feb 2026 | Viewed by 33 | Submission Open

Keywords: skin aging; chronological dermal aging; photo-aging; hormone therapy; menopause; estrogen-deficient skin; dermatosis; skin conditions

(This special issue belongs to the Section Medical Research)

What Is Life?—2nd Edition

edited by

Jacques Fantini

and André Brack

submission deadline 27 Feb 2026 | Viewed by 77 | Submission Open

Keywords: definition of life; origins of life; artificial intelligence; alphafold; synthetic biology; theoretical biology; quantum biology; water; time; and space; membrane systems; electrostatic potential; DNA; RNA; epigenetics; mutations; molecular interactions; chirality; artificial intelligence and life processes; early evolution of life; coevolution

Recent Insights in the Pathogenesis, Diagnosis, Prognosis and Treatment of Glomerular Disorders

edited by Adrian Constantin Covic and

Gener Ismail

submission deadline 28 Feb 2026 | 4 articles | Viewed by 3407 | Submission Open

Keywords: glomerular disorders; pathology; kidney biopsy; immunology; immunosuppresion; vasculitis

(This special issue belongs to the Section Medical Research)

Advances in Veterinary Infectious Diseases: Pathogenesis, Diagnostics, and Control Strategies

edited by

Hye-Mi Lee

submission deadline 28 Feb 2026 | Viewed by 24 | Submission Open

Keywords: veterinary infectious diseases; zoonoses; animal health; pathogen transmission; vaccine development; immunology; antiviral strategies; emerging pathogens; diagnostic tools; public health

(This special issue belongs to the Section Animal Science)

Green Medicine: Unraveling the Medicinal Effects of Plant Extracts and Functional Foods

edited by

Denis Nchang Che

and

Stefania Lamponi

submission deadline 24 Mar 2026 | 13 articles | Viewed by 20464 | Submission Open

Keywords: plant extracts; phytochemicals; inflammation; obesity; liver disease; oxidative stress; antioxidants; diabetes; skin damage; aging

(This special issue belongs to the Section Pharmaceutical Science)

Innovative Perspectives in Physical Therapy and Health

edited by

Carlos Romero-Morales

Gustavo Plaza-Manzano

and

Ricardo Ortega‐Santiago

submission deadline 30 Mar 2026 | 3 articles | Viewed by 4421 | Submission Open

Keywords: physical therapy; health; pain management; musculoskeletal disorders; ultrasonography; rehabilitation; innovative therapies

(This special issue belongs to the Section Medical Research)

Microvascular and Macrovascular Response in Healthy and Critically Ill

edited by Andrius Pranskunas and

Marius Brazaitis

submission deadline 30 Mar 2026 | 2 articles | Viewed by 929 | Submission Open

Keywords: microcirculation; glycocalyx; peripheral perfusion; systemic hemodynamic; body temperature; dynamic maneuvers; remote ischemic conditioning; exercise; adaptation

(This special issue belongs to the Section Physiology and Pathology)

Innovations, Utilization, and Safety of Psychiatric Drugs: Current Trends and Future Directions

edited by Josipa Bukić

submission deadline 30 Mar 2026 | 1 articles | Viewed by 541 | Submission Open

Keywords: psychiatric diseases; psychiatric medicine; psychiatric pharmacotherapy; psychiatric drugs

(This special issue belongs to the Section Pharmaceutical Science)

Biological Insights into Drug Safety for Vulnerable Populations

edited by

Dulce Estêvão

and

Margarida Espírito-Santo

submission deadline 30 Mar 2026 | Viewed by 250 | Submission Open

Keywords: drug safety; vulnerable populations; pharmacotherapy; drug metabolism and efficacy; pediatric medication safety; drug pharmacokinetics and pharmacodynamics

(This special issue belongs to the Section Pharmaceutical Science)

Advances in Skin-Related Disease: Pathogenesis and Novel Therapeutic Strategies

edited by