Non-alcoholic Fatty Liver in Everyday Clinical Practice: From Diagnosis to Therapy
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: closed (18 April 2024) | Viewed by 12780
Special Issue Editors
Interests: non-alcoholic fatty liver disease; metabolic-associated fatty liver disease; diabetes; clinical pharmacology
Special Issues, Collections and Topics in MDPI journals
Interests: psychopathology; mental illness; clinical health; clinical psychiatry; clinical psychology; sleep disorders; psychological assessment; psychosomatic medicine
Special Issue Information
Dear Colleagues,
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases encountered in everyday clinical practice. It is a very insidious disease because it often does not cause symptoms and is associated with the risk of life-threatening consequences. It has been proven that it increases the risk of liver complications (including fibrosis, cirrhosis, and hepatocellular carcinoma—HCC), metabolic complications (including type 2 diabetes and its complications), and is associated with the development of other pathologies (cardiovascular complications, including heart failure atrial fibrillation and chronic subclinical and clinical coronary syndrome), and non-HCC malignancies (including colorectal, breast, prostate, lung, and pancreatic). Recently, attention has also been paid to the relationship between NAFLD and chronic kidney disease and its impact on its severity. So far, there is an interesting discussion related to the mechanisms of development, the choice of tools for diagnosing fatty infiltration of the liver and the therapeutic standards of NAFLD. Despite the strong association of this pathology with obesity and insulin resistance, new mechanisms involved in the development of NAFLD are still being discovered. At the moment, no single marker with a highly sensitive and specific association with the presence of NAFLD has been identified, despite a wide choice (biopsy, imaging, and laboratory tests). Therefore, in the non-invasive diagnosis of this pathology, a number of helpful scales are used, taking into account the patient’s sex, age, anthropometric measurements, and selected laboratory parameters. NAFLD therapy is mainly based on appropriate diet, physical exercise, and pharmacotherapy aimed at reducing body weight. However, it should be remembered that NAFLD also occurs in thin people; therefore, the possibility of therapeutic intervention in other mechanisms of the development of this pathology is also suggested.
The purpose of our Special Issue is collecting papers, including original and review papers, related to the etiopathogenesis, diagnosis, complications, and treatment of patients with NAFLD based on current medical knowledge, which will enable the improvement of patient care in everyday clinical practice.
Dr. Kosmalski Marcin
Dr. Łukasz Mokros
Guest Editors
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