The Clinical Management of Liver Cirrhosis: Current Concepts, Recent Advances and Future Trends

Dear Colleagues,

Cirrhosis is among the most complex chronic diseases in humans and has a high impact on patients, caregivers, and national health services, generating a great human and economic burden. It is a tremendously heterogeneous and dynamic disease able to progress and regress between its different stages. During its natural course, two major periods can be identified: compensated (asymptomatic) and decompensated cirrhosis (current or previous history of variceal bleeding, ascites, jaundice, or encephalopathy). Further disease states have been identified, each of them with its own clinical, histological, hemodynamic, therapeutic, and prognostic characteristics. Systemic inflammation secondary to sustained translocation of bacterial products from the intestinal lumen to the systemic circulation aggravated by episodic bursts of bacterial translocation and/or proinflammatory precipitants (e.g., bacterial infections or alcoholic hepatitis) has been postulated as the key mechanism driving the progression within these stages. The current management of liver cirrhosis consists of suppressing the etiological factor and targeting key pathogenic factors of each of its complications. With this Special Issue, we hope to encourage submissions that discuss the current state of the art, address existing knowledge gaps, and focus on ongoing controversies related to pathogenesis, diagnostic, and therapeutic management of liver cirrhosis and its complications.

Dr. Jose Ignacio Fortea
Guest Editor

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