Next Article in Journal
A Cross-Sectional Study of Hyponatremia Associated with Acute Central Nervous System Infections
Next Article in Special Issue
Back to Basics: Recognition of Sepsis with New Definition
Previous Article in Journal
Is There Any Role for Super-Extended Limphadenectomy in Advanced Gastric Cancer? Results of an Observational Study from a Western High Volume Center
Previous Article in Special Issue
TSLP Exacerbates Septic Inflammation via Murine Double Minute 2 (MDM2) Signaling Pathway
Article

The Effect of the Intelligent Sepsis Management System on Outcomes among Patients with Sepsis and Septic Shock Diagnosed According to the Sepsis-3 Definition in the Emergency Department

1
Department of Emergency Medicine, Korea University Ansan Hospital, Jeokgeum-ro 123, Danwon-gu, Gyeonggi-do 15355, Korea
2
Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Jeokgeum-ro 123, Danwon-gu, Gyeonggi-do 15355, Korea
3
National Emergency Medical Center, National Medical Center, Eulji-ro 245, Jung-gu, Seoul 04564, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(11), 1800; https://doi.org/10.3390/jcm8111800
Received: 24 September 2019 / Revised: 23 October 2019 / Accepted: 24 October 2019 / Published: 27 October 2019
We developed a novel computer program, the Intelligent Sepsis Management System, based on Sepsis-3 definitions and 2016 Surviving Sepsis Campaign guidelines and performed a quasi-experimental pre-post study to assess its effect on compliance with the Surviving Sepsis Campaign guidelines and outcomes in patients with sepsis and septic shock. During the pre-period, patients were managed with usual care. During the post-period, patients were managed using the Intelligent Sepsis Management System upon arrival at the emergency department. A total of 631 patients were enrolled (pre-period, 316; post-period, 315). The overall compliance with the Surviving Sepsis Campaign guidelines’ bundle improved (pre-period 10.8% vs. post-period 54.6%; p < 0.001). The post-period showed significantly lower 30-day mortality than the pre-period (pre-period 37.3% vs. post-period 29.5%; p = 0.037), but was not a protective factor for 30-day mortality, with an adjusted hazard ratio (95% confidence interval) of 0.75 (0.55–1.04) (p = 0.151). The associated factors for 30-day mortality were age, sequential organ failure assessment score, overall compliance, and lactate levels. The 30-day mortality was significantly lower in the compliance group than in the non-compliance group (27.2% vs. 36.5%; p = 0.002). After implementation of the Intelligent Sepsis Management System, overall compliance with the Surviving Sepsis Campaign guidelines improved and was associated with reduced 30-day mortality. However, we could not verify the causal effect of this system on 30-day mortality. View Full-Text
Keywords: emergency department; mortality; sepsis; septic shock; Surviving Sepsis Campaign guidelines emergency department; mortality; sepsis; septic shock; Surviving Sepsis Campaign guidelines
Show Figures

Figure 1

MDPI and ACS Style

Song, J.; Cho, H.; Park, D.W.; Ahn, S.; Kim, J.Y.; Seok, H.; Park, J.; Moon, S. The Effect of the Intelligent Sepsis Management System on Outcomes among Patients with Sepsis and Septic Shock Diagnosed According to the Sepsis-3 Definition in the Emergency Department. J. Clin. Med. 2019, 8, 1800. https://doi.org/10.3390/jcm8111800

AMA Style

Song J, Cho H, Park DW, Ahn S, Kim JY, Seok H, Park J, Moon S. The Effect of the Intelligent Sepsis Management System on Outcomes among Patients with Sepsis and Septic Shock Diagnosed According to the Sepsis-3 Definition in the Emergency Department. Journal of Clinical Medicine. 2019; 8(11):1800. https://doi.org/10.3390/jcm8111800

Chicago/Turabian Style

Song, Juhyun, Hanjin Cho, Dae W. Park, Sejoong Ahn, Joo Y. Kim, Hyeri Seok, Jonghak Park, and Sungwoo Moon. 2019. "The Effect of the Intelligent Sepsis Management System on Outcomes among Patients with Sepsis and Septic Shock Diagnosed According to the Sepsis-3 Definition in the Emergency Department" Journal of Clinical Medicine 8, no. 11: 1800. https://doi.org/10.3390/jcm8111800

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop