Special Issue "Diabetic Nephropathy"
Deadline for manuscript submissions: closed (31 March 2015)
Dr. Juan F. Navarro-González
Diabetic kidney disease describes the alterations of the kidney that are produced by diabetes mellitus, including the functional, structural and clinical abnormalities. Nowadays, this important complication of diabetes has become the most frequent cause of end-stage renal disease. The pathophysiology of DKD comprises the interaction of both genetic and environmental determinants that trigger a complex network of pathophysiological events, which involve all the compartments of the kidneys. Diabetic kidney disease progresses gradually over years through different stages, from reversible glomerular hyperfiltration at the beginning to renal failure at the final phase. Importantly, new forms of evolution have been described recently. The screening and early diagnosis of diabetic kidney disease, which is based on the measurement of urinary albumin excretion, is critical for an adequate management and for the prevention of renal disease progression.
Prof. Dr. Juan F. Navarro-González
Dr. Desirée Luis
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- diabetic nephropathy
- glomerular filtration barrier
- tubulo-interstitial damage
- renin-angiotensin system