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Association between Osteopontin Promoter Gene Polymorphisms and Haplotypes with Risk of Diabetic Nephropathy

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Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
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Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
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Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
*
Author to whom correspondence should be addressed.
Academic Editors: Juan F. Navarro-González and Desirée Luis
J. Clin. Med. 2015, 4(6), 1281-1292; https://doi.org/10.3390/jcm4061281
Received: 10 March 2015 / Revised: 12 May 2015 / Accepted: 29 May 2015 / Published: 10 June 2015
(This article belongs to the Special Issue Diabetic Nephropathy)
Background: Osteopontin (OPN) C-443T promoter polymorphism has been shown as a genetic risk factor for diabetic nephropathy (DN) in type 2 diabetic patients (T2D). Methods: In the present study we investigated the association of three functional promoter gene polymorphisms C-443T, delG-156G, and G-66T and their haplotypes with the risk of DN and estimated Glomerular Filtration Rate (eGFR) in Asian Indians T2D patients using Real time PCR based Taqman assay. A total of 1165 T2D patients, belonging to two independently ascertained Indian Asian cohorts, were genotyped for three OPN promoter polymorphisms C-443T (rs11730582), delG-156G (rs17524488) and G-66T (rs28357094). Results: -156G allele and GG genotypes (delG-156G) and haplotypes G-C-G and T-C-G (G-66T, C-443T, delG-156G) were associated with decreased risk of DN and higher eGFR. Haplotype G-T-delG and T-T-delG (G-66T, C-443T, delG-156G) were identified as risk haplotypes, as shown by lower eGFR. Conclusion: This is the first study to report an association of OPN promoter gene polymorphisms; G-66T and delG-156G and their haplotypes with DN in T2D. Our results suggest an association between OPN promoter gene polymorphisms and their haplotypes with DN. View Full-Text
Keywords: diabetic nephropathy; haplotypes; Osteopontin promoter gene polymorphism; type 2 diabetes; eGFR diabetic nephropathy; haplotypes; Osteopontin promoter gene polymorphism; type 2 diabetes; eGFR
MDPI and ACS Style

Cheema, B.S.; Iyengar, S.; Sharma, R.; Kohli, H.S.; Bhansali, A.; Khullar, M. Association between Osteopontin Promoter Gene Polymorphisms and Haplotypes with Risk of Diabetic Nephropathy. J. Clin. Med. 2015, 4, 1281-1292.

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