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J. Clin. Med. 2015, 4(9), 1761-1773;

Non-Proteinuric Diabetic Nephropathy

Cátedra de Riesgo Vascular, Facultad de Medicina, Universidad de Salamanca, Salamanca 37007, Spain
Servicio de Nefrologia, Hospital Infanta Cristina, Badajoz 06070, Spain
Author to whom correspondence should be addressed.
Academic Editors: Juan F. Navarro-González and Desirée Luis
Received: 13 May 2015 / Revised: 11 August 2015 / Accepted: 26 August 2015 / Published: 7 September 2015
(This article belongs to the Special Issue Diabetic Nephropathy)
Full-Text   |   PDF [211 KB, uploaded 7 September 2015]


Diabetic nephropathy patients traditionally show significant macroalbuminuria prior to the development of renal impairment. However, this clinical paradigm has recently been questioned. Epidemiological surveys confirm that chronic kidney disease (CKD) diagnosed by a low glomerular filtration rate (GFR) is more common in diabetic patients than in the non-diabetic population but a low number of patients had levels of proteinuria above that which traditionally defines overt diabetic nephropathy (>500 mg/g). The large number of patients with low levels of proteinuria suggests that the traditional clinical paradigm of overt diabetic nephropathy is changing since it does not seem to be the underlying renal lesion in most of diabetic subjects with CKD. View Full-Text
Keywords: chronic kidney disease; proteinuria; microalbuminuria; diabetes mellitus chronic kidney disease; proteinuria; microalbuminuria; diabetes mellitus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Robles, N.R.; Villa, J.; Gallego, R.H. Non-Proteinuric Diabetic Nephropathy. J. Clin. Med. 2015, 4, 1761-1773.

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