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Infective Endocarditis: What Is New in the Clinical Research: 2nd...
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Infective Endocarditis: What Is New in the Clinical Research: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 1975

Special Issue Editor

Dr. Petros Ioannou

E-Mail Website
Guest Editor
School of Medicine, University of Crete, Heraklion, Greece
Interests: infectious diseases; internal medicine; HIV/AIDS; infective endocarditis; blood-stream infections
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to announce the release of the second volume of the Special Issue “Infective Endocarditis: What Is New in the Clinical Research”.

Infective endocarditis (IE) is a rare disease that still poses significant challenges. Despite significant advances made in medical knowledge and technology that have improved the diagnosis and treatment of infectious diseases in the last few decades, IE is still associated with significant morbidity and mortality, while its epidemiology is changing. Patients are now older in age, and microbiology demographics have changed due to the increase in healthcare-associated infection, leading to the more frequent identification of Gram-negative microorganisms as causes of IE. On the other hand, the increasing rates of antimicrobial resistance have resulted in a more frequent diagnosis of IE caused by microorganisms with few therapeutic options. Finally, the increasing use of immunosuppression in patients with cancer, autoimmune diseases and transplantation has led to an increase in the diagnosis of IE caused by rare pathogens. This Special Issue will focus on the current clinical research on IE, and present the latest data on the changing epidemiology, microbiology, diagnostic methods and treatment of IE, as well as its outcomes.

Dr. Petros Ioannou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infective endocarditis
  • vegetation
  • native valve
  • prosthetic valve
  • aortic valve
  • mitral valve
  • cardiac device
  • bloodstream infection
  • bacteremia

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Published Papers (1 paper)

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Review

15 pages, 1361 KiB  
Review
Infective Endocarditis by Listeria Species—A Systematic Review
by Despoina Kypraiou, Maria Konstantaraki, Andreas G. Tsantes and Petros Ioannou
J. Clin. Med. 2024, 13(19), 5887; https://doi.org/10.3390/jcm13195887 - 2 Oct 2024
Viewed by 1546
Abstract
Infective endocarditis (IE) is a disease associated with significant morbidity and mortality. It is more commonly caused by Gram-positive cocci, but Gram-positive bacilli may seldom cause the disease. Listeria monocytogenes is an aerobic Gram-positive coccobacillus and a foodborne and opportunistic pathogen most commonly [...] Read more.
Infective endocarditis (IE) is a disease associated with significant morbidity and mortality. It is more commonly caused by Gram-positive cocci, but Gram-positive bacilli may seldom cause the disease. Listeria monocytogenes is an aerobic Gram-positive coccobacillus and a foodborne and opportunistic pathogen most commonly causing gastrointestinal infections, even though bacteremia, sepsis, meningitis, and fetal infections may also occur. Listeria IE has rarely been described, with most reports being case reports or case series. Thus, the characteristics of this disease remain largely unknown. This systematic review aimed to present all published Listeria IE studies and describe their characteristics. A search of PubMed, Scopus, and the Cochrane Library for studies providing information on epidemiology, clinical findings, treatment, and outcome of Listeria IE cases was performed. A total of 54 studies containing data from 62 patients were included. Among all patients, 64.5% were male; the median age was 69 years. Among all patients, 54.8% had a history of a prosthetic valve. The aortic valve was the most commonly affected, followed by the mitral. Fever, heart failure, and embolic phenomena were the most commonly encountered clinical findings. The only isolated species was L. monocytogenes. Antimicrobial resistance was relatively low for aminopenicillins and aminoglycosides, the most commonly used antimicrobials for treating L. monocytogenes IE. Surgery was performed in 27.4% of patients. Mortality was 37.1%. Patients who survived were more likely to have had a prosthetic valve, to have necessitated transesophageal echocardiography for the diagnosis, to have mitral valve IE, and to have had surgical management; however, no factor was identified in a multivariate logistic regression model as an independent factor for overall mortality. Full article
(This article belongs to the Special Issue Infective Endocarditis: What Is New in the Clinical Research: 2nd Edition)
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