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Special Issue "Orthopaedics: Medicine and Mechanisms"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 20 August 2019

Special Issue Editor

Guest Editor
Prof. Dr. Gerald Atkins

Centre for Orthopaedic & Trauma Research, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
Website | E-Mail
Interests: periprosthetic joint infection; osteolysis; osteoarthritis; osteoporosis; osteocyte; bone remodelling

Special Issue Information

Dear Colleagues,

The last 20 years has seen an explosion in knowledge of how the musculoskeletal system functions to self-repair and how these organ-, tissue-, cellular-, and molecular-level mechanisms are corrupted to contribute to various bone pathologies. This has occurred side by side with improvements in the surgical and medical management of many orthopaedic and trauma related conditions, including end-stage osteoarthritis, osteoporosis leading to fragility fracture, rheumatoid arthritis, and skeletal malignancies. While orthopaedic intervention is often thought of as the ‘last resort’, the causative pathology often develops over a long period of time, sometimes over the patient’s lifetime. This suggests that a greater understanding of the underlying pathology could lead to earlier or alternative interventions. Other pathologies, including periprosthetic joint infection (PJI) and periprosthetic loosening or fracture, while secondary to a primary surgical intervention, nevertheless relate to the patient’s current state of health and medical history. In this Special Issue entitled “Orthopaedics: Medicine and Mechanisms”, we will delve deeper into the underlying mechano-medico-biologic causes of orthopaedic pathologies and how these are being addressed by more than improvements in surgical practices.

Prof. Dr. Gerald Atkins
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Orthopaedics
  • Trauma
  • Biologic mechanism
  • Bone pathology

Published Papers (1 paper)

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Research

Open AccessArticle
Osteoarthritis Changes Hip Geometry and Biomechanics Regardless of Bone Mineral Density—A Quantitative Computed Tomography Study
J. Clin. Med. 2019, 8(5), 669; https://doi.org/10.3390/jcm8050669
Received: 15 April 2019 / Revised: 7 May 2019 / Accepted: 8 May 2019 / Published: 12 May 2019
PDF Full-text (1253 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
We aimed to compare proximal femur geometry and biomechanics in postmenopausal women with osteoarthritis (OA) and/or osteoporosis (OP), using quantitative computed tomography (QCT). A retrospective analysis of QCT scans of the proximal femur of 175 postmenopausal women was performed. Morphometric and densitometric data [...] Read more.
We aimed to compare proximal femur geometry and biomechanics in postmenopausal women with osteoarthritis (OA) and/or osteoporosis (OP), using quantitative computed tomography (QCT). A retrospective analysis of QCT scans of the proximal femur of 175 postmenopausal women was performed. Morphometric and densitometric data of the proximal femur were used to evaluate its biomechanics. We found, 21 had a normal bone mineral density (BMD), 72 had osteopenia, and 81 were diagnosed with OP. Radiographic findings of hip OA were seen in 43.8%, 52.8%, and 39.5% of the normal BMD, osteopenic, and OP groups, respectively (p < 0.05). OA was significantly correlated with total hip volume (r = 0.21), intertrochanteric cortical volume (r = 0.25), and trochanteric trabecular volume (r = 0.20). In each densitometric group, significant differences in hip geometry and BMD were found between the OA and non-OA subgroups. Hip OA and OP often coexist. In postmenopausal women, these diseases coexist in 40% of cases. Both OA and OP affect hip geometry and biomechanics. OA does so regardless of densitometric status. Changes are mostly reflected in the cortical bone. OA leads to significant changes in buckling ratio (BR) in both OP and non-OP women. Full article
(This article belongs to the Special Issue Orthopaedics: Medicine and Mechanisms)
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J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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