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Placenta-Mediated Conditions of Pregnancy: Prevention, Diagnosis and Management
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Placenta-Mediated Conditions of Pregnancy: Prevention, Diagnosis and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 2967

Special Issue Editor

Dr. Amihai Rottenstreich

E-Mail Website
Guest Editor
1. Maternal Fetal Medicine Service, Northwell Health, New York, NY 11042, USA
2. Allen and Frances Adler Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10065, USA
Interests: maternal fetal medicine; obstetric medicine; placenta-mediated complications; bleeding and thrombotic complications of pregnancy; preterm birth; perinatology

Special Issue Information

Dear Colleagues,

Placenta-mediated conditions include hypertensive disorders of pregnancy, fetal growth restriction, placental abruption, and late pregnancy loss. These complications are leading causes of maternal, fetal, and neonatal morbidity and mortality worldwide. In recent decades, many efforts have been made in order to improve the prevention, diagnosis and management of placenta-mediated conditions. Despite significant advancements and the accumulation of a large body of evidence, many other issues remain that must be addressed.

In this Special Issue of the Journal of Clinical Medicine, we are offering a platform to highlight the broad diversity of research performed across this field. This Special Issue will focus on new insights, current challenges and controversies, recent advances, and future perspectives in the field of placenta-mediated conditions. We anticipate that the research presented will promote fruitful discussions in the maternal–fetal medical community that will translate into the adoption of best practice applications in clinical, public health and policy settings.

Dr. Amihai Rottenstreich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • placenta-mediated conditions
  • preeclampsia
  • fetal growth restriction
  • placental abruption
  • pregnancy loss

Published Papers (3 papers)

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Research

9 pages, 220 KiB  
Article
The Outcome after Laser Therapy of Monochorionic Twin Pregnancies Complicated by Twin-Twin Transfusion Syndrome with Coexistent Selective Fetal Growth Restriction
by Javier U. Ortiz, Johanna Guggenberger, Oliver Graupner, Eva Ostermayer, Bettina Kuschel and Silvia M. Lobmaier
J. Clin. Med. 2024, 13(8), 2432; https://doi.org/10.3390/jcm13082432 - 21 Apr 2024
Viewed by 531
Abstract
Background: Most previous studies evaluated outcomes of twin–twin transfusion syndrome (TTTS) without considering the coexistence of selective fetal growth restriction (sFGR). The objectives of this study were to compare twin survival and pregnancy complications after laser therapy of TTTS with and without sFGR. [...] Read more.
Background: Most previous studies evaluated outcomes of twin–twin transfusion syndrome (TTTS) without considering the coexistence of selective fetal growth restriction (sFGR). The objectives of this study were to compare twin survival and pregnancy complications after laser therapy of TTTS with and without sFGR. Methods: For this purpose, a retrospective cohort study including 98 monochorionic diamniotic twins and three dichorionic triamniotic triplets treated in a single tertiary center was conducted. Results: Overall, 46 twins had selective fetal growth restriction (26 type I, 13 type II, 7 type III). At birth, donor survival (61% vs. 91%), double survival (57% vs. 82%), and overall survival (75% vs. 88%) were significantly lower in the group with coexistent sFGR. Recipient survival (89% vs. 86%), miscarriage (7% vs. 2%), PPROM < 32 weeks (48% vs. 29%), and preterm delivery < 32 weeks (52% vs. 45%) were not significantly higher in the group with coexistent sFGR. Donor twins with sFGR type I (69% vs. 91%) and types II–III (50% vs. 91%) showed significantly lower survival than those without sFGR. Multivariate regression analysis identified sFGR and its subtypes as independent predictors of donor demise. Conclusions: the coexistence of sFGR in TTTS pregnancies was associated with poor donor outcomes and is probably the most important predictor of donor survival. Full article
(This article belongs to the Special Issue Placenta-Mediated Conditions of Pregnancy: Prevention, Diagnosis and Management)
19 pages, 565 KiB  
Article
Role of IL-6, IL-10 and TNFα Gene Variants in Preterm Birth
by Mirta Kadivnik, Deni Plečko, Kristina Kralik, Nena Arvaj and Jasenka Wagner
J. Clin. Med. 2024, 13(8), 2429; https://doi.org/10.3390/jcm13082429 - 21 Apr 2024
Viewed by 492
Abstract
Background: The association of gene variants for interleukin 6 (IL-6) (rs1800796), interleukin 10 (IL-10) (rs1800896) and tumor necrosis factorα (TNFα (rs1800629) with the occurrence of spontaneous preterm birth (PTB) was investigated to determine whether these genetic variants are a risk factor. Methods: A [...] Read more.
Background: The association of gene variants for interleukin 6 (IL-6) (rs1800796), interleukin 10 (IL-10) (rs1800896) and tumor necrosis factorα (TNFα (rs1800629) with the occurrence of spontaneous preterm birth (PTB) was investigated to determine whether these genetic variants are a risk factor. Methods: A total of 199 blood samples from pregnant women who had given birth prematurely and 200 control blood samples were analyzed to determine single nucleotide polymorphisms (SNPs) of genes for IL-6 (rs1800796), IL-10 (rs1800896) and TNFα (rs1800629). The control samples were samples from pregnant women with term delivery. The isolation of DNA was performed on mini-spin columns according to the manufacturer’s protocol. The quality and purity of the isolated DNA were tested using a Qubit 3 fluorometer. Genotyping was performed with an ABI PRISM 7500 SDS using TaqMan SNP genotyping assays. The genotypes obtained were analyzed using the 7500 Software v2.3 package. Results: Carriers of the A/A genotype for the rs1800629 SNP of the TNFα gene have a 4.81 times greater chance of late-onset PTB compared to carriers of the G/G and A/G genotypes in the recessive inheritance model. The presence of the G/G genotype in the recessive inheritance model compared with the G/A and A/A genotypes for the rs1800896 SNP of the IL-10 gene represents a potentially protective factor, with mothers in the term-birth group having an almost 2-fold lower odds of PTB in general and an almost 10-fold lower odds of early PTB. On the other hand, carriers of the A/G genotype of rs1800896 have a 1.54-fold higher chance of preterm birth in general and a 1.6-fold higher chance of late preterm birth in the superdominant inheritance model compared to the A/A and G/G genotypes in the group of mothers with PTB. In this study, no association was found between PTB and the rs1800796 SNP of the IL-6 gene. Conclusions: rs1800629 in mothers was associated with PTB. rs1800896 shows a potentially protective effect for the occurrence of PTB in this study. No association was found between PTB and rs1800796. Full article
(This article belongs to the Special Issue Placenta-Mediated Conditions of Pregnancy: Prevention, Diagnosis and Management)
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13 pages, 2253 KiB  
Article
COVID-19 and Pregnancy: A Dangerous Mix for Bone Turnover and Metabolism Biomarkers in Placenta and Colostrum
by Javier Diaz-Castro, Juan M. Toledano, Javier Sanchez-Romero, Africa Caño Aguilar, Estefanía Martín-Alvarez, Maria Puche-Juarez, Jorge Moreno-Fernandez, Maria Pinar-Gonzalez, Sonia Prados, María Paz Carrillo, Susana Ruiz-Duran, Catalina De Paco Matallana and Julio J. Ochoa
J. Clin. Med. 2024, 13(7), 2124; https://doi.org/10.3390/jcm13072124 - 6 Apr 2024
Viewed by 1657
Abstract
Background: In pregnant women, COVID-19 can alter the metabolic environment, cell metabolism, and oxygen supply of trophoblastic cells and, therefore, have a negative influence on essential mechanisms of fetal development. The purpose of this study was to investigate, for the first time, [...] Read more.
Background: In pregnant women, COVID-19 can alter the metabolic environment, cell metabolism, and oxygen supply of trophoblastic cells and, therefore, have a negative influence on essential mechanisms of fetal development. The purpose of this study was to investigate, for the first time, the effects of COVID-19 infection during pregnancy with regard to the bone turnover and endocrine function of several metabolic biomarkers in colostrum and placenta. Methods: One hundred and twenty-four pregnant mothers were recruited from three hospitals between June 2020 and August 2021 and assigned to two groups: Control group and COVID-19 group. Metabolism biomarkers were addressed in placental tissue and colostrum. Results: Lipocalin-2 and resistin levels were higher in the placenta, revealing an underlying pro-inflammatory status in the gestation period for mothers suffering from COVID-19; a decrease in GLP-1 and leptin was also observed in this group. As for adiponectin, resistin, and insulin, their concentrations showed an increase; a decrease in GLP-1, leptin, and PYY was also reported in the colostrum of mothers suffering from COVID-19 compared with the control group. Conclusions: As for bone turnover, placental samples from mothers with COVID-19 showed lower levels of OPG, while DKK-1 increased compared with the control group. Colostrum samples showed higher levels of OPG, SOST, and PTH in the COVID-19 group, a fact that could have noteworthy implications for energy metabolism, fetal skeletal development, and postnatal bone density and mineralization. Further research is needed to explain the pathogenic mechanism of COVID-19 that may affect pregnancy, so as to assess the short-term and long-term outcomes in infants’ health. Full article
(This article belongs to the Special Issue Placenta-Mediated Conditions of Pregnancy: Prevention, Diagnosis and Management)
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