Special Issue "Helicobacter Pylori Infection and Related Diseases"
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: closed (31 March 2021).
Interests: Helicobacter pylori infection; epidemiology; diagnosis and treatment; Celiac disease; GERD; IBD
Interests: helicobacter pylori infection; epidemiology; children; pathophysiology; gastro-intestinal diseases; extra gastro-intestinal disorders; autoimmune disorders
Helicobacter pylori is the most common infection in humans, with 50% of the world's population being affected. The incidence and prevalence of infection vary across and within countries, being more common in low-income countries compared to high-income countries. The infection is acquired, usually, in childhood and persists unless treated. Risk factors capable of influencing the rate of bacterial infection are socioeconomic status and living conditions, including overcrowding, number of siblings, sharing a bed, and a lack of running water, among others. Human gastric mucosa appear to be the major reservoir of infection. However, in some circumstances, farm animals and/or contaminated food may contribute to the spread of bacteria.
Colonization by H. pylori stimulates a robust inflammatory and immune response resulting invariably in tissue injury. The infection is always associated with a chronic active gastritis and, in long-lasting gastritis, precancerous lesions, such as atrophy and dysplasia, may develop. Clinical outcomes, including peptic ulcer, gastric cancer, and gastric-mucosa-associated lymphoid tissue lymphoma, are the result of a complex interaction among host characteristics, bacteria virulence, and environmental factors.
Current evidence suggests that H. pylori infection also plays a role in a number of extra-gastrointestinal diseases, probably induced by the occurrence of molecular mimicry and maintenance of a low-grade inflammation. This Special Issue aims to highlight new contributions in the field of H. pylori infection and related diseases in children and adult individuals.
Prof. Maria Pina Dore
Prof. Giovanni Mario Pes
Manuscript Submission Information
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- Helicobacter pylori infection and epidemiology
- Helicobacter pylori infection and children
- Helicobacter pylori infection and pathophysiology
- Helicobacter pylori infection and gastro-intestinal diseases
- Helicobacter pylori infection and extra gastro-intestinal disorders
- Helicobacter pylori infection and autoimmune disorders.