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Review

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

by 1,*, 2,3,4 and 3,4
1
Department of Gastroenterology, Frankston Hospital, Peninsula Health, Melbourne 3199, Australia
2
Department of Geriatric Medicine, The Canberra Hospital, ACT Health, Canberra 2605, Australia
3
Department of Orthopedic Surgery, The Canberra Hospital, ACT Health, Canberra 2605, Australia
4
Australian National University Medical School, Canberra 2605, Australia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(10), 3253; https://doi.org/10.3390/jcm9103253
Received: 21 August 2020 / Revised: 28 September 2020 / Accepted: 7 October 2020 / Published: 12 October 2020
(This article belongs to the Special Issue Helicobacter Pylori Infection and Related Diseases)
Osteoporosis (OP) and osteoporotic fractures (OFs) are common multifactorial and heterogenic disorders of increasing incidence. Helicobacter pylori (H.p.) colonizes the stomach approximately in half of the world’s population, causes gastroduodenal diseases and is prevalent in numerous extra-digestive diseases known to be associated with OP/OF. The studies regarding relationship between H.p. infection (HPI) and OP/OFs are inconsistent. The current review summarizes the relevant literature on the potential role of HPI in OP, falls and OFs and highlights the reasons for controversies in the publications. In the first section, after a brief overview of HPI biological features, we analyze the studies evaluating the association of HPI and bone status. The second part includes data on the prevalence of OP/OFs in HPI-induced gastroduodenal diseases (peptic ulcer, chronic/atrophic gastritis and cancer) and the effects of acid-suppressive drugs. In the next section, we discuss the possible contribution of HPI-associated extra-digestive diseases and medications to OP/OF, focusing on conditions affecting both bone homeostasis and predisposing to falls. In the last section, we describe clinical implications of accumulated data on HPI as a co-factor of OP/OF and present a feasible five-step algorithm for OP/OF risk assessment and management in regard to HPI, emphasizing the importance of an integrative (but differentiated) holistic approach. Increased awareness about the consequences of HPI linked to OP/OF can aid early detection and management. Further research on the HPI–OP/OF relationship is needed to close current knowledge gaps and improve clinical management of both OP/OF and HPI-related disorders. View Full-Text
Keywords: Helicobacter pylori infection; osteoporosis; fractures; falls; medications; management Helicobacter pylori infection; osteoporosis; fractures; falls; medications; management
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MDPI and ACS Style

Fisher, L.; Fisher, A.; Smith, P.N. Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review). J. Clin. Med. 2020, 9, 3253. https://doi.org/10.3390/jcm9103253

AMA Style

Fisher L, Fisher A, Smith PN. Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review). Journal of Clinical Medicine. 2020; 9(10):3253. https://doi.org/10.3390/jcm9103253

Chicago/Turabian Style

Fisher, Leon, Alexander Fisher, and Paul N. Smith 2020. "Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)" Journal of Clinical Medicine 9, no. 10: 3253. https://doi.org/10.3390/jcm9103253

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