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Skin Wound Healing: Clinical Updates and Perspectives
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Skin Wound Healing: Clinical Updates and Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (20 November 2025) | Viewed by 5236

Special Issue Editors

Dr. András Bánvölgyi

E-Mail Website
Guest Editor
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Interests: dermatology; wound care; hidradenitis suppurativa; basal cell carcinoma; artificial intelligence
Dr. Norbert Kiss

E-Mail Website
Guest Editor
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
Interests: dermatology; wound care; skin cancer; imaging; multiphoton microscopy; high-frequency ultrasound
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute original articles and review papers to be published in our Special Issue open for submissions entitled ‘Skin Wound Healing: Clinical Updates and Perspectives’ in the Journal of Clinical Medicine.

Wound healing is a complex and dynamic process that plays a crucial role in tissue repair and regeneration. Despite advances in medical science, impaired wound healing remains a significant clinical challenge, particularly in chronic wounds, diabetic ulcers, and post-surgical recovery. Understanding the biological mechanisms, novel therapeutic strategies, and emerging technologies in wound care is essential for improving patient outcomes.

This Special Issue will focus on the latest updates in skin wound healing, including novel biomaterials, bioengineered skin substitutes, and clinical medicine approaches. Advances in wound assessment, imaging techniques, and diagnostic biomarkers will also be highlighted. Additionally, we welcome research on the role of artificial intelligence and telemedicine in wound management, as well as innovations in personalized and precision medicine for optimizing healing outcomes.

Clinical research is highly encouraged for submission to this Special Issue.

Dr. András Bánvölgyi
Dr. Norbert Kiss
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermatology
  • wound care
  • diagnosis
  • biomaterials
  • negative pressure wound therapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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10 pages, 967 KB  
Article
Etoricoxib-Induced Fixed Erythema
by Corina Porr, Dana M. Harris, Anca Vidrighin, Alina Catana, Cosmina Diaconu, Emi M. Preda, Mirela L. Popa and Elena C. Berghea
J. Clin. Med. 2025, 14(23), 8504; https://doi.org/10.3390/jcm14238504 - 30 Nov 2025
Cited by 3 | Viewed by 824
Abstract
Background: Fixed drug eruption (FDE) is a non-immediate, CD8+ T cell–mediated hypersensitivity reaction characterized by well-demarcated erythematous–violaceous plaques that recur at the same site after re-exposure to the causative drug. Although NSAIDs and antibiotics are the most common triggers, various other medications may [...] Read more.
Background: Fixed drug eruption (FDE) is a non-immediate, CD8+ T cell–mediated hypersensitivity reaction characterized by well-demarcated erythematous–violaceous plaques that recur at the same site after re-exposure to the causative drug. Although NSAIDs and antibiotics are the most common triggers, various other medications may induce FDE, and genetic susceptibility has been linked to specific HLA alleles. Methods: We conducted a clinical evaluation supported by patch testing, oral drug provocation, and assessment of therapeutic alternatives to identify the causative agent and confirm delayed-type hypersensitivity. Results: We report the case of a 53-year-old woman with essential hypertension, autoimmune thyroiditis, and renal lithiasis who developed well-demarcated erythematous plaques with central vesiculation and moderate pruritus on the dorsal hand and posterior calf approximately 8 h after ingestion of a 60 mg etoricoxib tablet. Patch testing was negative, while oral challenge confirmed etoricoxib-induced FDE; celecoxib was subsequently evaluated as a potential safe alternative. Conclusions: This case underscores the importance of an integrated diagnostic approach—including careful history, clinical examination, and confirmatory testing—to accurately diagnose delayed cutaneous drug reactions and to identify safe therapeutic options for patients. Full article
(This article belongs to the Special Issue Skin Wound Healing: Clinical Updates and Perspectives)
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13 pages, 1069 KB  
Article
When Rewiring Fails—The Enduring Role of the Pectoralis Major Flap in Sternal Wound Reconstruction
by Viktoria Koenig, Alexandra Christ, Maximilian Monai, Martin Andreas, Daniel Zimpfer, Wolfgang Happak and Paul Werner
J. Clin. Med. 2025, 14(23), 8376; https://doi.org/10.3390/jcm14238376 - 26 Nov 2025
Viewed by 440
Abstract
Background: Deep sternal wound infections (DSWIs) remain a serious complication after median sternotomy, often requiring complex wound management strategies. While modern approaches include vacuum-assisted closure (VAC) and plating techniques, the pedicled pectoralis major muscle flap (PMF) continues to play a pivotal role [...] Read more.
Background: Deep sternal wound infections (DSWIs) remain a serious complication after median sternotomy, often requiring complex wound management strategies. While modern approaches include vacuum-assisted closure (VAC) and plating techniques, the pedicled pectoralis major muscle flap (PMF) continues to play a pivotal role in surgical reconstruction, especially in cases with sternal destruction or osteomyelitis. Methods: In this retrospective single-centre analysis, 166 patients with DSWI following cardiac surgery were reviewed. Clinical data, comorbidities, laboratory parameters, and surgical management were evaluated. Logistic regression was performed to assess predictors for reinfection and need for reoperation. Results: Initial wound revision was most frequently performed using sternal rewiring (60.2%), followed by reconstruction with a pectoralis major flap (33.7%). Despite initial surgical treatment, 27.1% of patients developed post-revision wound healing disturbances, and 24.1% ultimately required a second surgical intervention. Among second-time procedures, VAC therapy (32.5%) and PMF reconstruction (20.0%) were the most common approaches. Reinfection was significantly associated with higher preoperative EuroSCOREs (p = 0.044), while initial rewiring carried a higher risk of treatment failure compared to the pectoralis major flap (p = 0.0024). Conclusions: In the setting of sternal destruction or osteomyelitis, the pectoralis major muscle flap remains a fast, effective, and robust solution. Despite its long-standing use, it continues to offer excellent vascularized coverage and infection control in complex DSWI cases. Full article
(This article belongs to the Special Issue Skin Wound Healing: Clinical Updates and Perspectives)
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13 pages, 1013 KB  
Article
Effect of Dry Carbonic Acid Baths on Blood Rheological Parameters in Patients with Venous Leg Ulcers
by Patrycja Dolibog, Paweł Tomasz Dolibog, Mikołaj Łanocha, Marcelina Paruzel, Tomasz Pryzwan, Aleksandra Frątczak, Wiesław Pilis, Daria Chmielewska, Sławomir Grzegorczyn and Beata Bergler-Czop
J. Clin. Med. 2025, 14(18), 6614; https://doi.org/10.3390/jcm14186614 - 19 Sep 2025
Viewed by 994
Abstract
Background: Chronic venous insufficiency (CVI) is one of the main causes of venous leg ulcers. Rheological disorders of the blood, such as changes in viscosity, hematocrit, and erythrocyte aggregation and deformability, can impair microcirculation and impede healing. Carbonic acid (CO2) [...] Read more.
Background: Chronic venous insufficiency (CVI) is one of the main causes of venous leg ulcers. Rheological disorders of the blood, such as changes in viscosity, hematocrit, and erythrocyte aggregation and deformability, can impair microcirculation and impede healing. Carbonic acid (CO2) dry baths are a non-invasive physical method that can affect microcirculation and blood parameters, and this study aimed to assess their effectiveness in ulcer healing and in modifying selected blood rheological parameters in patients with CVI. Methods: This prospective, controlled study enrolled 23 participants (11 patients with active venous leg ulcers and 12 healthy controls). The intervention group underwent ten sessions of dry CO2 baths, performed twice weekly for 5 weeks. No randomization was applied. Ulcer healing was assessed planimetrically, and blood rheological parameters (hematocrit, blood and plasma viscosity, erythrocyte deformability index [EI], aggregation index [AI], aggregation amplitude [AMP], and half-time of aggregation [T1/2]) were measured before and after therapy. Results: Following the intervention, the ulcer area decreased significantly (median 3.35 cm2 to 1.74 cm2; p < 0.01), as did ulcer circumference (7.33 cm to 5.87 cm; p < 0.01). Hematocrit increased (median 40.25% to 41.50%; p < 0.05), and blood viscosity values at low shear rates approached those of the control group. In contrast, erythrocyte deformability (EI) and aggregation indices (AI, AMP, T1/2) showed no statistically significant intragroup changes, although intergroup differences persisted. Pain intensity decreased significantly (VAS 6.0 to 3.5 cm; p < 0.05). Conclusions: CO2 dry baths support the treatment of venous ulcers by improving microcirculation and reducing pain. Their impact on blood rheology may have clinical significance, especially as an adjunct to therapy in chronic venous insufficiency. However, the relatively small sample size (n = 23) should be considered a limitation when interpreting these findings. Full article
(This article belongs to the Special Issue Skin Wound Healing: Clinical Updates and Perspectives)
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Review

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23 pages, 1164 KB  
Review
Platelet-Rich Plasma (PRP) and Recombinant Growth Factor Therapies in Cutaneous Wound Healing: Mechanisms, Clinical Applications, and Future Directions
by Abu-Bakr Ahmed, Spencer Thatcher, Joshua Khorsandi, Zahra Ahmed, Michael Lee, Adam Jaouhari, Braydon Bond and Aftab Merchant
J. Clin. Med. 2025, 14(23), 8583; https://doi.org/10.3390/jcm14238583 - 3 Dec 2025
Cited by 1 | Viewed by 2454
Abstract
Background: Chronic cutaneous wounds such as diabetic foot ulcers, venous leg ulcers, pressure injuries, and burns remain a global clinical burden. These wounds are often arrested in inflammatory or ischemic stages due to impaired angiogenesis and growth factor deficiencies. Biologic therapies, such [...] Read more.
Background: Chronic cutaneous wounds such as diabetic foot ulcers, venous leg ulcers, pressure injuries, and burns remain a global clinical burden. These wounds are often arrested in inflammatory or ischemic stages due to impaired angiogenesis and growth factor deficiencies. Biologic therapies, such as platelet-rich plasma (PRP) and recombinant growth factors, aim to restore these deficits and accelerate repair. Methods: A narrative review of PubMed and Google Scholar (2015–2025) identified 64 English-language studies, including randomized controlled trials, meta-analyses, and translational investigations evaluating PRP and recombinant growth factors in wound healing. Results: Randomized trials and meta-analyses show that adjunctive autologous PRP increases complete wound closure versus standard care in chronic ulcers, including diabetic foot and venous leg ulcers (odds ratios ≈ 2–8), and improves healing rates in pressure injuries (odds ratio ≈ 3.4), without increasing adverse events. In diabetic foot ulcers, PDGF-BB and EGF, together with PRP, consistently improve complete healing and reduce ulcer area. In burns, topical EGF and bFGF shorten healing time by ~3 days in superficial partial-thickness wounds and by >5 days in deeper burns, with generally improved scar outcomes. Conclusions: PRP offers broad, autologous biologic activation, while recombinant growth factors deliver high-potency, targeted precision. Together, they represent complementary regenerative strategies that can shorten healing times and improve outcomes in chronic wounds. Standardized multicenter trials quantifying cytokine composition, cost-effectiveness, and long-term limb-salvage benefit are warranted to guide their integration into routine clinical practice. Full article
(This article belongs to the Special Issue Skin Wound Healing: Clinical Updates and Perspectives)
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