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Volume 14
Issue 23
10.3390/jcm14238504
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Etoricoxib-Induced Fixed Erythema

by
Corina Porr
1,
Dana M. Harris
2,
Anca Vidrighin
3,*,
Alina Catana
4,
Cosmina Diaconu
5,*,
Emi M. Preda
6,7,
Mirela L. Popa
8 and
Elena C. Berghea
9,10
1
Allergology Department, Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania
2
Internal Medicine Department, Mayo Clinic, Jacksonville, FL 32224, USA
3
Department of Paediatrics, Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania
4
Hematology Department, Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania
5
Department of Nursing and Dental Medicine, Faculty of Medicine, Lucian Blaga University, 550024 Sibiu, Romania
6
Department of Radiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
7
Department of Radiology and Medical Imaging, “Foișor” Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania
8
Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania
9
Department of Paediatrics, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
10
Department of Clinical Allergology and Clinical Immunology, Marie S. Curie Emergency Children’s Clinical Hospital, 077120 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(23), 8504; https://doi.org/10.3390/jcm14238504 (registering DOI)
Submission received: 3 October 2025 / Revised: 18 November 2025 / Accepted: 28 November 2025 / Published: 30 November 2025
(This article belongs to the Special Issue Skin Wound Healing: Clinical Updates and Perspectives)
Versions Notes

Abstract

Background: Fixed drug eruption (FDE) is a non-immediate, CD8+ T cell–mediated hypersensitivity reaction characterized by well-demarcated erythematous–violaceous plaques that recur at the same site after re-exposure to the causative drug. Although NSAIDs and antibiotics are the most common triggers, various other medications may induce FDE, and genetic susceptibility has been linked to specific HLA alleles. Methods: We conducted a clinical evaluation supported by patch testing, oral drug provocation, and assessment of therapeutic alternatives to identify the causative agent and confirm delayed-type hypersensitivity. Results: We report the case of a 53-year-old woman with essential hypertension, autoimmune thyroiditis, and renal lithiasis who developed well-demarcated erythematous plaques with central vesiculation and moderate pruritus on the dorsal hand and posterior calf approximately 8 hours after ingestion of a 60 mg etoricoxib tablet. Patch testing was negative, while oral challenge confirmed etoricoxib-induced FDE; celecoxib was subsequently evaluated as a potential safe alternative. Conclusions: This case underscores the importance of an integrated diagnostic approach—including careful history, clinical examination, and confirmatory testing—to accurately diagnose delayed cutaneous drug reactions and to identify safe therapeutic options for patients.
Keywords: fixed drug eruption; etoricoxib; cutaneous drug reaction; patch test; oral challenge test; non-steroidal anti-inflammatory drugs fixed drug eruption; etoricoxib; cutaneous drug reaction; patch test; oral challenge test; non-steroidal anti-inflammatory drugs

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MDPI and ACS Style

Porr, C.; Harris, D.M.; Vidrighin, A.; Catana, A.; Diaconu, C.; Preda, E.M.; Popa, M.L.; Berghea, E.C. Etoricoxib-Induced Fixed Erythema. J. Clin. Med. 2025, 14, 8504. https://doi.org/10.3390/jcm14238504

AMA Style

Porr C, Harris DM, Vidrighin A, Catana A, Diaconu C, Preda EM, Popa ML, Berghea EC. Etoricoxib-Induced Fixed Erythema. Journal of Clinical Medicine. 2025; 14(23):8504. https://doi.org/10.3390/jcm14238504

Chicago/Turabian Style

Porr, Corina, Dana M. Harris, Anca Vidrighin, Alina Catana, Cosmina Diaconu, Emi M. Preda, Mirela L. Popa, and Elena C. Berghea. 2025. "Etoricoxib-Induced Fixed Erythema" Journal of Clinical Medicine 14, no. 23: 8504. https://doi.org/10.3390/jcm14238504

APA Style

Porr, C., Harris, D. M., Vidrighin, A., Catana, A., Diaconu, C., Preda, E. M., Popa, M. L., & Berghea, E. C. (2025). Etoricoxib-Induced Fixed Erythema. Journal of Clinical Medicine, 14(23), 8504. https://doi.org/10.3390/jcm14238504

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