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Antioxidants, Physical Exercise and Cardiovascular Disease: Nutritional and Lifestyle Interventions

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 5 August 2025 | Viewed by 851

Special Issue Editors


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Guest Editor
1. Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal
2. Research Center for Active Living and Wellbeing (LiveWell), Instituto Politécnico de Bragança, 5300-253 Bragança, Portugal
3. Department of Sports, Instituto Politécnico de Bragança, 5300-253 Bragança, Portugal
4. CI-ISCE, ISCE Douro, 4560-708 Penafiel, Portugal
Interests: chronic pain; physical exercise; sports Science
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90010-150, RS, Brasil
Interests: cardiovascular diseases; antioxidants; microbiology; nutrition; diet

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Guest Editor
Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil
Interests: analysis of total phenolics in foods and extracts; intestinal health; sports nutrition; nutrition; diet

Special Issue Information

Dear Colleagues,

Cardiovascular health is a major focus of modern medicine, requiring comprehensive approaches that integrate nutrition and lifestyles. Cardiovascular diseases (CVDs) continue to be the leading cause of death worldwide, placing a significant burden on healthcare systems globally. Prevention and effective management of these conditions are therefore of crucial importance.

Emerging research has highlighted the vital role of antioxidants and physical exercise as effective interventions in combating CVDs. Antioxidants, present in various foods and supplements, play a crucial role in neutralizing oxidative stress and reducing inflammation. Oxidative stress and inflammation are key factors in the pathogenesis of several cardiovascular diseases, including atherosclerosis, hypertension and heart failure. Supplementation with antioxidants, such as vitamins C and E, polyphenols and flavonoids, has demonstrated significant potential in modulating these pathological processes.

At the same time, physical exercise is widely recognized as a powerful intervention for promoting cardiovascular health. Regular exercise, whether aerobic or anaerobic, improves cardiovascular function, helps control blood pressure, reduces cholesterol levels and promotes the maintenance of healthy body weight. Furthermore, physical exercise has beneficial effects in modulating oxidative stress and inflammation, complementing the effects of antioxidants.

However, the maximum therapeutic potential of these interventions can be achieved when combined in a synergistic manner. The combination of antioxidant regimens and physical exercise programs may offer an integrated and effective approach to the prevention and treatment of CVD. Recent studies indicate that antioxidants can improve the body’s ability to deal with exercise-induced oxidative stress, while physical exercise can increase the effectiveness of antioxidants. This Special Issue seeks to explore the intersection between antioxidant supplementation and physical exercise in the context of cardiovascular disease. Topics that will be covered include the following:

  • Effects of antioxidants on cardiovascular health;
  • Combination of antioxidants and physical exercise;
  • Holistic nutritional interventions;
  • Molecular and cellular aspects;
  • Clinical implications and public health.

This Special Issue of Nutrients accepts submissions of research articles, review articles, systematic reviews and meta-analyses, as well as short communications.

Dr. Pedro Miguel Forte
Dr. Patrick Türck
Prof. Dr. Ceres Mattos Della Lucia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • exercise
  • health
  • cardiovascular
  • lifestyle

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Published Papers (1 paper)

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Research

17 pages, 3165 KiB  
Article
Blueberry Extract and Resistance Training Prevent Left Ventricular Redox Dysregulation and Pathological Remodeling in Experimental Severe Pulmonary Arterial Hypertension
by Luciano Bernardes Leite, Leôncio Lopes Soares, Luiz Otávio Guimarães-Ervilha, Sebastião Felipe Ferreira Costa, Sara Caco dos Lúcio Generoso, Mirielly Alexia Miranda Xavier, Thainá Iasbik-Lima, Leandro Licursi de Oliveira, Ceres Mattos Della Lucia, Sara Elis Bianchi, Valquíria Linck Bassani, Flavio Gilberto Herter, Patrick Turck, Alex Sander da Rosa Araujo, Pedro Forte, Emily Correna Carlo Reis, Mariana Machado-Neves and Antônio José Natali
Nutrients 2025, 17(7), 1145; https://doi.org/10.3390/nu17071145 - 26 Mar 2025
Viewed by 337
Abstract
Objective: To investigate whether the regular administration of blueberry extract and low-intensity resistance exercise training (RT), either alone or in combination, during the development of monocrotaline (MCT)-induced severe pulmonary arterial hypertension (PAH) in rats protect the left ventricle (LV) from redox dysregulation and [...] Read more.
Objective: To investigate whether the regular administration of blueberry extract and low-intensity resistance exercise training (RT), either alone or in combination, during the development of monocrotaline (MCT)-induced severe pulmonary arterial hypertension (PAH) in rats protect the left ventricle (LV) from redox dysregulation and pathological remodeling. Methods: Groups of seven male Wistar rats were formed for the experiment: sedentary control; sedentary hypertensive; sedentary hypertensive blueberry; exercise hypertensive; and exercise hypertensive blueberry. PAH was experimentally induced through a single intraperitoneal administration of MCT at a dose of 60 mg/kg. One day after injection, the blueberry groups started receiving a daily dose of blueberry extract (100 mg/kg) by gavage, while the exercise groups initiated a three-week program of RT (ladder climbing; 15 climbs carrying 60% of maximum load; one session/day; 5 times/week). Echocardiographic evaluations were conducted 23 days after injection, and the rats were euthanized the next day to harvest LV tissue. Results: Separately, blueberry extract and RT mitigated augments in pulmonary artery resistance, LV tissue redox dysregulation (i.e., increased PC levels) and detrimental remodeling (i.e., reduced inflammation), and reductions in ejection fraction (EF) and fractional shortening (FS) caused by PAH. The combination of treatments prevented reductions in EF and FS, along with the development of a D-shaped LV. Conclusions: blueberry extract and moderate-intensity resistance training administered during the development of MCT-induced severe PAH in rats prevented LV redox dysregulation and pathological remodeling, thereby preserving its function. Full article
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