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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research on Malaria: Molecular and Biochemical Perspectives submission deadline 30 May 2025 | Viewed by 202 | Submission Open
Keywords: malaria; vectors; therapies; resistance; cellular mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Cardiomyopathy: From Molecular Pathology to Treatment submission deadline 30 May 2025 | Viewed by 197 | Submission Open
Keywords: obesity; myocardial fibrosis; subclinical myocardial dysfunction; fibrotic remodeling; microRNAs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Rapeseed: Genetic Breeding, Key Trait Mining and Genome
edited by Hongbo Chao
submission deadline 30 May 2025 | Viewed by 197 | Submission Open
Keywords: rapeseed (Brassica napus L.); genetic breeding; genomic improvement; molecular markers; genome-wide association studies (GWAS); multi-omics integration; CRISPR gene editing; marker-assisted selection (MAS); stress resistance traits; yield and oil content improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Biocomposite Hydrogels for Biomedical Applications submission deadline 30 May 2025 | Viewed by 186 | Submission Open
Keywords: hydrogels; biocomposite; micro/nanoparticles; electrospun fibers; inorganic particles; tissue engineering; drug delivery; 3D printing
(This special issue belongs to the Section Materials Science)
Protein Modification: New Insights
edited by
submission deadline 30 May 2025 | Viewed by 184 | Submission Open
Keywords: post-translational modifications (PTMs); side chain modifications; backbone modifications; analytical protein chemistry; mass spectrometry
(This special issue belongs to the Section Biochemistry)
Exploring the Genetics in Rare Diseases: A Genomic Odyssey
edited by
submission deadline 30 May 2025 | Viewed by 168 | Submission Open
Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Markers and Genetic Diversity in Plants
edited by Eugenija Kupčinskienė
submission deadline 30 May 2025 | Viewed by 162 | Submission Open
Keywords: plant populations; genetic diversity; molecular diversity; invasion; invasive alien species; pollution; climate change; habitat; conservation; endangered and rare species; DNA markers; molecular markers; sequencing
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular and Cellular Mechanisms of Bitter Taste Receptors in Immune Disease submission deadline 30 May 2025 | Viewed by 162 | Submission Open
Keywords: bitter taste receptors; TAS2Rs; immune disease; immunity response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Amyotrophic Lateral Sclerosis (ALS): Pathogenesis and Treatments submission deadline 30 May 2025 | Viewed by 156 | Submission Open
Keywords: amyotrophic lateral sclerosis; therapeutic applications; extracellular-vesicles; gene variants; RNA metabolism; mitochondrial dysfunction; oxidative stress; neuroinflammation; protein misfolding; muscle impariment
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Chronic Liver Disease and Liver Failure
edited by Paolo Gallo
submission deadline 30 May 2025 | Viewed by 156 | Submission Open
Keywords: cirrhosis; portal hypertension; liver failure; advanced chronic liver disease; sarcopenia and malnutrition; ascites; medical treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Topics in Polymer Crystallization
edited by Lei Zhang
submission deadline 30 May 2025 | Viewed by 152 | Submission Open
Keywords: polymer crystal; nucleation and growth; crystallization under extreme conditions; characterization of crystal structure
(This special issue belongs to the Section Macromolecules)
Density Functional Theory and Its Application in Atomic Collision Models
edited by
submission deadline 30 May 2025 | Viewed by 149 | Submission Open
Keywords: density functional theory; time-dependent density functional theory; finite-temperature density functional theory; ensemble density functional theory; atom collision models; electron stopping power
(This special issue belongs to the Section Physical Chemistry, Theoretical and Computational Chemistry)
New Insights into Chronic Inflammatory Demyelinating Polyneuropathy and Neuroimmunological Diseases
edited by
submission deadline 30 May 2025 | Viewed by 146 | Submission Open
Keywords: chronic inflammatory demyelinating polyneuropathy (CIDP); multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); autoimmune encephalitis; paraneoplastic neurological syndrome; Guillain-Barre syndrome (GBS); myositis; blood-brain barrier; blood-nerve barrier
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Emerging Nanomaterials and Their Environmental Implications
edited by Gao Xiao
submission deadline 30 May 2025 | Viewed by 142 | Submission Open
Keywords: nanomaterials; molecular level; water purification; bioavailability; environmental effects; renewable energy solutions; ecotoxicology and sustainability; degradation pathways; toxicity
(This special issue belongs to the Section Materials Science)
Cellular Plasticity in Health and Diseases
edited by
submission deadline 30 May 2025 | Viewed by 137 | Submission Open
Keywords: stem cells; cytokines; extracellular matrix; cell differentiation; cell locomotion; cell growth; tissue repair; chronic inflammation; dysplasia; hyperplasia; premalignant lesions; cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of HLA (Human Leucocyte Antigen) in Human Diseases
edited by Jeane Eliete Laguila Visentainer
submission deadline 30 May 2025 | Viewed by 133 | Submission Open
Keywords: HLA (human leukocyte antigen); molecular immunology; autoimmune diseases; HLA genetics; antigen presentation; HLA and cancer; immunotherapy and HLA; immune responses; immunity and HLA; infectious diseases and HLA; innate and adaptive immunity; organ transplantation and HLA; HLA and immune responses; HLA genotypes and susceptibility; autoimmunity and HLA; HLA and infectious diseases; HLA and personalized therapies; molecular mechanisms of HLA; HLA mutations; experimental models of HLA; HLA and inflammation; HLA biomarkers; HLA and immunosuppression; immune tolerance and HLA; immune evasion by HLA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanism in Multiple Sclerosis and Related Disorders: 3rd Edition
edited by and Kazuo Fujihara
submission deadline 30 May 2025 | Viewed by 131 | Submission Open
Keywords: neurodegeneration; multiple sclerosis; NMOSD; MOGAD; disease-modifying treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Diversity of Life: Light to Heavy Metal Coordination Compounds of Biological Relevance
edited by
submission deadline 30 May 2025 | Viewed by 126 | Submission Open
Keywords: coordination compounds; metal-based drugs; antimicrobial; anti-inflammatory; antiviral agents; cancer therapy; drug delivery systems
(This special issue belongs to the Section Biochemistry)
Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition) submission deadline 30 May 2025 | Viewed by 125 | Submission Open
Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial– mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways
(This special issue belongs to the Section Molecular Oncology)
Sarcomas: From Molecular Insights to Personalized Therapies
edited by
submission deadline 30 May 2025 | Viewed by 124 | Submission Open
Keywords: soft tissue sarcoma; biomarkers; molecular mechanisms; experimental models; clinical factors associated with sarcoma development
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into the Pathophysiology of Placenta Accreta Spectrum
edited by Jessian L. Munoz
submission deadline 30 May 2025 | Viewed by 115 | Submission Open
Keywords: placenta accreta; invasive placenta; trophoblasts; placenta; high-risk pregnancy; placenta previa; in vitro fertilization; biomarkers; multi-omics research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Action and Cytotoxicity of Platinum-Based Therapeutics
edited by
submission deadline 30 May 2025 | Viewed by 114 | Submission Open
Keywords: platinum-based drugs; cancer therapy; cisplatin; drug resistance; nanodrugs; targeted delivery systems; molecular mechanisms; systemic toxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Innate Immune System in Renal Diseases
edited by
submission deadline 30 May 2025 | Viewed by 111 | Submission Open
Keywords: innate immune system; acquired immunity; complement system; dendritic cells; monocyte/macrophages (Mϕ); polymorphonuclear leukocytes; NK/NKT cells; innate lymphoid cells (ILCs); AKI; CKD
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Melanoma: From Molecular Mechanisms to Therapeutics
edited by Dorota Ciołczyk-Wierzbicka
submission deadline 30 May 2025 | Viewed by 98 | Submission Open
Keywords: melanoma; molecular mechanism; signaling pathways; genetic mutations; cancer therapy/treatment; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Myosin: Structure, Function and Evolution
edited by Barbara Baryłko and
submission deadline 30 May 2025 | Viewed by 98 | Submission Open
Keywords: myosins; actin; molecular motors; organelle trafficking; endocytosis; secretion; membrane tension; RNA transport; force generation; ATPase activity
(This special issue belongs to the Section Macromolecules)
Antiviral Strategies Targeting Capsid Proteins: Intervention from Assembly to Function
edited by
submission deadline 30 May 2025 | Viewed by 98 | Submission Open
Keywords: viral capsid protein; assembly modulator/intervention; virus variants; antiviral therapeutics; assembly– disassembly
(This special issue belongs to the Section Macromolecules)
Radiation Toxicity in Cells: New Insights
edited by
submission deadline 30 May 2025 | Viewed by 92 | Submission Open
Keywords: radiation; ultraviolet light; X-rays; γ radiation; microwaves; cell death pathways; DNA damage; cell membrane; ROS; signaling pathways; animal studies
(This special issue belongs to the Section Molecular Toxicology)
Research on Synthetic Medicinal Chemistry
edited by Alberto Ongaro
submission deadline 30 May 2025 | Viewed by 91 | Submission Open
Keywords: drug development; lead optimization; degraders; PROTACs; bioactive molecules
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Basis and Treatment of Creatine Deficiency Syndromes
edited by Andreas Schulze
submission deadline 30 May 2025 | Viewed by 87 | Submission Open
Keywords: AGAT; GAMT; creatine transporter; SCL6A8; GATM; creatine deficiency; guanidinoacetate; animal models; cell models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Nanomaterials in Plant Metabolism
edited by
submission deadline 30 May 2025 | Viewed by 86 | Submission Open
Keywords: nanoparticles; nanomaterials; abiotic stress; photosynthesis; chlorophyll fluorescence; signal molecules; antioxidant activity; chlorophyll fluorescence; photosynthetic machinery; reactive oxygen species; thylakoid membranes; signal molecules; physiological and stressful conditions; plant metabolism
(This special issue belongs to the Section Molecular Nanoscience)
Mechanisms and Implications of Traumatic Brain Injury and Neuroinflammation
edited by
submission deadline 30 May 2025 | Viewed by 84 | Submission Open
Keywords: traumatic brain injury; head trauma; neuroinflammation; secondary injury; microglia
(This special issue belongs to the Section Molecular Neurobiology)
New Insights in Plant Abiotic Stress
edited by
submission deadline 31 May 2025 | 10 articles | Viewed by 27318 | Submission Open
Keywords: plant abiotic stress; heat; cold; high salinity; heavy metals
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular and Cellular Mechanisms of Epilepsy—3rd Edition
edited by
submission deadline 31 May 2025 | 7 articles | Viewed by 16735 | Submission Open
Keywords: epilepsy; epilepsy models; epileptogenesis; preventing epilepsy; neuroinflammation; neuroprotection; synaptic plasticity; neuron– astrocyte interaction
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Biology of the Thyroid Cancer and Thyroid Dysfunctions
edited by Vija Lavinia
submission deadline 31 May 2025 | 9 articles | Viewed by 15878 | Submission Open
Keywords: animal models; apoptosis; autophagy; cancer biomarker; cancer epidemiology; cancer prevention; cancer screening; cholesterol metabolism; clinical trial; DNA repair; epigenomics; genome instability; genomic database; genomics; invasion; metabolomics; metastasis; methylation; microarray; microRNA; molecular diagnostics; molecular tumor pathology; next-generation sequencing; noncoding RNA; omics; personalized medicine; prognosis; proteomics; radionuclide therapy; signaling pathway; SNP genotyping; targeted therapy; theranostics; thyroid cancer; hyperthyroidism; therapeutic targets; translational cancer research; treatment response; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Studies on Lactic Acid Bacteria and Their Products in Health and Diseases: 2nd Edition submission deadline 31 May 2025 | 7 articles | Viewed by 14565 | Submission Open
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research in Uterine Biology and Pathophysiology, 2nd Edition
edited by
submission deadline 31 May 2025 | 7 articles | Viewed by 12884 | Submission Open
Keywords: human reproduction; fertility; endometrial and myometrial functionality; estrogen and progesteron receptors; sex hormones; endometrial hyperplasia; endometrial cancer and uterine sarcoma; embryo implantation; pregnancy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Transcriptional Regulation in Plant Development: 2nd Edition submission deadline 31 May 2025 | 14 articles | Viewed by 11971 | Submission Open
Keywords: environmental stresses; plant development; vegetative development; plant physiology and biochemistry; transcriptional regulation; plant– environment interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Plant Extracts and Bioactive Molecules with Potential Benefits for Human Health submission deadline 31 May 2025 | 5 articles | Viewed by 8796 | Submission Open
Keywords: medicinal plants; plant extracts; bioactive phytocompound identification and quantification; pharmacological activity; health benefits; phytotherapy; plant-based diet; functional foods
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Oral Cancer and Disease in Humans and Animals
edited by Maria Leonor Delgado and
submission deadline 31 May 2025 | 5 articles | Viewed by 8470 | Submission Open
Keywords: cancer biomarkers; mitosis; cell cycle; animal models; comparative pathology; cancer stem cell; cancer epidemiology; cancer risk factors; cancer biomarker; tissue microarray; immunohistochemistry; microarray; microRNA; molecular diagnostics; proteomics; tumor microenvironment; treatment response; targeted therapy; immunotherapy; translation cancer research; zoonosis; gross pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mass Spectrometry Approaches as Clinical Diagnostic/Prognostic Tools
edited by
submission deadline 31 May 2025 | 2 articles | Viewed by 8221 | Submission Open
Keywords: mass spectrometry; quantitative analysis; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Topics in Metal Complexes: Pharmacological Activity, 2nd Edition submission deadline 31 May 2025 | 4 articles | Viewed by 6353 | Submission Open
Keywords: metal complexes; polyoxometalates; biological activity; pharmacokinetic parameters; mechanistic analysis; cancer/neurodegenerative diseases; innovative strategies; laboratory diagnostics; clinical studies
(This special issue belongs to the Section Molecular Pharmacology)
Medical Value of Metal Complexes and Plant-Derived Compounds: Biological Evaluation, Health Effects, Challenges, and Future Opportunities submission deadline 31 May 2025 | 4 articles | Viewed by 5382 | Submission Open
Keywords: bioactive compounds; metals; metal complexes; polyoxometalates; modern-age diseases; toxicity; therapeutic importance; novel applications
(This special issue belongs to the Section Molecular Pharmacology)
Computational Studies in Drug Design and Discovery
edited by
submission deadline 31 May 2025 | 2 articles | Viewed by 4451 | Submission Open
Keywords: molecular docking; homology modeling; repositioning; virtual screening; QSAR; molecular dynamics; ADME prediction  
(This special issue belongs to the Section Molecular Informatics)
Molecular Oncogenetics: Insights into Cancer Development, Drug Resistance, and Personalized Treatments submission deadline 31 May 2025 | 2 articles | Viewed by 4126 | Submission Open
Keywords: oncogenetics; molecular alterations; genomics; transcriptomics; hereditary cancer syndromes; drug resistance mechanisms; tailored treatments; next-generation sequencing
(This special issue belongs to the Section Molecular Oncology)
Coronavirus Disease (COVID-19): Pathophysiology (6th Edition) submission deadline 31 May 2025 | 2 articles | Viewed by 3343 | Submission Open
Keywords: SARS-CoV-2; coronavirus; pandemic; viral diseases; pediatrics; inflammation; immune cells; macrophages; pneumonia; vaccines; cytokines; cytokine storm; PIMS; immunity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapies of Colorectal Cancer: 4th Edition submission deadline 31 May 2025 | 3 articles | Viewed by 3114 | Submission Open
Keywords: transforming growth factor beta (TGF-β ) signaling; genetic alterations; molecular targeted therapy precision medicine
(This special issue belongs to the Section Molecular Oncology)
Molecular Recognition and Biosensing
edited by
submission deadline 31 May 2025 | 1 articles | Viewed by 2988 | Submission Open
Keywords: molecular recognition; biosensor; nanomaterials; aptamer; nucleic acids; sensitivity
(This special issue belongs to the Section Biochemistry)
The Role of Natural Products in Drug Discovery submission deadline 31 May 2025 | 4 articles | Viewed by 2767 | Submission Open
Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry
(This special issue belongs to the Section Molecular Pharmacology)
Novel Molecular Pathways in Oncology, 3rd Edition
edited by
submission deadline 31 May 2025 | 2 articles | Viewed by 2450 | Submission Open
Keywords: molecular pathway involved in tumorigenesis; cancer therapy; targeted therapy; anticancer drugs; brain cancer; oral cancer; gastrointestinal cancer
(This special issue belongs to the Section Molecular Oncology)
Multiomics and Functional Foods: Molecular Characterization, Structures and Biological Activities
edited by and Jun Yang
submission deadline 31 May 2025 | 2 articles | Viewed by 1907 | Submission Open
Keywords: multiomics technologies; functional foods; characterization; structures; biological activities; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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